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MetabolomicsMulti-Omic Analysis and Platelet Function Distinguish Treatment Responses to Hydroxytyrosol in Cardiovascular Risk
Many polyphenols have been recognized for their antioxidant and health benefits. The present study attempted, for the first time, to determine the effects of daily oral intake of β-cyclodextrin-encapsulated hydroxytyrosol (HT) on plasma platelet reactivity and proteomic and metabolomic profiles of p...
2025-06-30 | MTBLS12336 | MetaboLights
MetabolomicsLimited oxygen availability in standard cell culture alters metabolism and function in terminally differentiated cells

Cell culture is generally considered to be hyperoxic. However, the importance of cellular oxygen consumption is often underappreciated, with rates of oxygen consumption often sufficient to cause hypoxia at cell monolayers. We initially focused on cultured adipocytes as a terminally differentiated...

2024-02-21 | MTBLS6677 | MetaboLights
TranscriptomicsA Genomic Score Prognostic of Outcome in Trauma Patients
Physiological, anatomical, and clinical laboratory analytic scoring systems (APACHE, Injury Severity Score (ISS)) have been utilized, with limited success, to predict outcome following injury. We hypothesized that a peripheral blood leukocyte gene expression score could predict outcome, including mu...
ORGANISM(S): Homo sapiens 
2009-04-12 | E-GEOD-11375 | biostudies-arrayexpress
ProteomicsCombining high resolution and exact calibration to boost statistical power: A well-calibrated score function for high-resolution MS2
This project reanalzyes data from 4 other projects. Information about the samples can be found in the following four publications. The four samples used in this study include a ocean metaproteome sample, a human sample, a E. coli sample, and a Plamodium falciparum sample. B. N. Pease, E. L. Huttli...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum (isolate 3D7) Escherichia coli 
2018-09-19 | PXD009265 | Pride
E. coli Score function Ocean Human Plasmodium 
MetabolomicsUnraveling the Mechanisms of Propofol-Induced Psychological Dependence: A Multi-Omics Approach Linked to Gut Microbiota in Hippocampal Function

Introduction: Drug abuse is becoming a global public health crisis. According to the United Nations, the number of drug users worldwide has increased dramatically over the past decade, with a surge in the number of drug abusers. The problem was exacerbated by the expanding market for illicit drug...

2025-05-12 | MTBLS12337 | MetaboLights
MetabolomicsSex-Driven Differences in the Rumen Microbe-Metabolite-Epithelial Transport Axis: An Integrated Multi-Omics Study of Rumen Function in Male and Female Zhongwei Goats
This study investigates sex-driven differences in rumen metabolism in male and female Zhongwei goats. Rumen fluid samples were analyzed using untargeted LC-MS metabolomics in both positive and negative ion modes. Metabolites were separated by ultra-high-performance liquid chromatography and detected...
2026-08-31 | MTBLS15319 | MetaboLights
TranscriptomicsSignatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study
We performed whole blood transcriptome analysis on a total of 70 critically injured patients (Injury Severity Score [ISS] >25) in the hyperacute time period within 2 hours of injury, at 24h and again at 72h. We compared transcriptome findings in 36 critically injured patients with those of 6 patient...
ORGANISM(S): Homo sapiens 
2017-07-06 | E-MTAB-5882 | biostudies-arrayexpress
ProteomicsBiopsy proteome score performs well as an effect measure in a gluten-challenge trial of coeliac disease
Objective Development of novel treatments for coeliac disease (CeD) is dependent on precise tools to monitor changes in gluten-induced mucosal damage. Current histology measures are subjective and difficult to standardise. Biopsy proteome scoring is an objective alternative to histology which is bas...
ORGANISM(S): Homo sapiens (Human) 
2025-04-08 | PXD050655 | Pride
Human Proteome score Gut biopsy Evosep Timstofflex Clinical trial 
TranscriptomicsTwo Histone/Protein Acetyltransferases, CBP and p300, Are Indispensable for Foxp3+ T-regulatory Cell Development and Function
T-regulatory (Treg) cells are important to immune homeostasis, and Treg cell deficiency or dysfunction leads to autoimmune disease. An histone/protein acetyltransferase (HAT), p300, was recently found important for Treg function and stability, but further insights into the mechanisms by which p300 o...
ORGANISM(S): Mus musculus 
2014-08-12 | E-GEOD-60318 | biostudies-arrayexpress
ProteomicsProteomics analysis of proteins co-immunoprecipitated with MIDN-Flag in PC-12 cells
We have previously identified midnolin (MIDN) as a genetic risk factor for Parkinson's disease. However, the molecular entity of MIDN that regulates neuronal phenotypes remains unclear. To investigate the molecular function of MIDN, we examined proteins associated with MIDN in PC-12 cells. We perfor...
ORGANISM(S): Rattus Rattus (black Rat) 
2024-09-13 | PXD053265 | JPOST Repository
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