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MetabolomicsOxidative phosphorylation is a metabolic vulnerability of endocrine therapy and palbociclib resistant metastatic breast cancers
Resistance to endocrine treatments and CDK4/6 inhibitors is considered a near-inevitability in most patients with estrogen receptor positive breast cancers (ER + BC). By genomic and metabolomics analyses of patients' tumours, metastasis-derived patient-derived xenografts (PDX) and isogenic cell line...
2023-06-27 | MTBLS3342 | MetaboLights
ProteomicsIdentifying candidate protein markers of acute kidney injury in acute decompensated heart failure using sheep kidney cortex
A quarter of patients with acute decompensated heart failure (ADHF) experience acute kidney injury (AKI), an abrupt loss of kidney function that doubles the risk of death at one-year. There is a critical need to identify early markers for AKI in ADHF, however, no protein candidates have been validat...
ORGANISM(S): Ovis aries 
2022-01-19 | PXD028983 | Pride
Adhf Kidney Sheep Swath-ms Tripletof Acute kidney injury 
UnknownImpaired nuclear PTEN function drives macrocephaly, lymphadenopathy and late-onset cancer in PTEN hamartoma tumour syndrome.
Not available
S-EPMC12817337 | biostudies-literature
UnknownIn-depth characterization of a new patient-derived xenograft model for metaplastic breast carcinoma to identify viable biologic targets and patterns of matrix evolution within rare tumor types.
Not available
S-EPMC8732292 | biostudies-literature
UnknownSafety, tolerability, and immunogenicity of the Ebola Sudan chimpanzee adenovirus vector vaccine (cAd3-EBO S) in healthy Ugandan adults: a phase 1, open-label, dose-escalation clinical trial.
Not available
S-EPMC10837320 | biostudies-literature
UnknownIdentifying phenotypic expansions for congenital diaphragmatic hernia plus (CDH+) using DECIPHER data.
Not available
S-EPMC9474674 | biostudies-literature
UnknownDe novo and inherited TCF20 pathogenic variants are associated with intellectual disability, dysmorphic features, hypotonia, and neurological impairments with similarities to Smith-Magenis syndrome.
Not available
S-EPMC6393995 | biostudies-literature
GenomicsNIDDK IBD Genetics Consortium Ulcerative Colitis Genome-Wide Association Study

This dataset contains data for 1,028 white, non-Hispanic, European ancestry individuals with ulcerative colitis who were included in a genome-wide association study published by Silverberg et al. (2009). These individuals were ascertained in North America and selected to have either left-sided ...

phs000345.v1.p1 | EGA
Genomics7635cfb5-4bb5-44fa-9d28-3760b584ba69 - samples
This dataset contains CTCF ChIP-sequencing data from seven samples (six tumor samples and one tumor derived cell line). Following library amplification, DNA fragments were sequenced using Illumina HiSeq 2000 paired-end sequencing resulting in 14 FASTQ files.
EGAD00001008806 | EGA
Genomicsena-DATASET-dkfz_b062-23-02-2018-16:41:10:412-192 - samples
This dataset contains ChIP sequencing data from 24 patients. ChIP of 5–10 mg flash-frozen primary ependymoma tumour was performed using 5 mg H3K27ac antibody per ChIP experiment. The enriched DNA has been sequenced on a Illumina HiSeq2000 instrument in paired-end mode. Up to two lanes per sampl...
EGAD00001003979 | EGA
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