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GenomicNHLBI TOPMed: The Genetic Epidemiology of Asthma in Costa Rica

This administrative supplement to the project, "The Genetic Epidemiology of Asthma in Costa Rica" (R37 HL066289) is in response to NOT-HL-14-029 to perform whole genome sequencing (WGS) on existing NHLBI populations. We focus on asthma because of its public health significance. Asthma affe...

phs000988 | dbGaP
MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
UnknownMenu labeling, calories, and nutrient density: Evidence from chain restaurants.
Not available
S-EPMC7205205 | biostudies-literature
ProteomicsPCP-MS analysis of insulin resistance in C2C12 myotubes with or without acute insulin stimulation
To study dynamic remodelling of protein complexes, C2C12 myotubes were treated with 0.5 mM palmitic acid for 24 h to induce insulin resistance (IR) and then stimulated with or without acute 100 nM insulin for 30 min followed by PCP-MS(n=3 each. Samples were lysed in non-denaturing buffer, separated ...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-29 | PXD075147 | Pride
Protein correlation profiling C2c12 Insulin resistance 
ProteomicsqXL-MS of insulin resistance in C2C12 myotubes
C2C12 myotubes were made insulin resistant with 0.5 mM palmitic acid for 24 h along with non-treated controls and then each group stimulated with or without 100 nM insulin for 30 min (n=4 each). Cells were then cross-linked with 2 mM of tPhoX for a further 30 min in the presence of insulin and the r...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-29 | PXD077371 | Pride
Tmt C2c12 Tphox 
ProteomicsqXL-MS of insulin resistance in mouse skeletal muscle
We established a whole tissue qXL-MS workflow to investigate proteome-wide changes in protein:protein interactions in mouse skeletal muscle insulin resistance (IR). Mice were feed a standard chow diet or a high fat diet (HFD) for 12 weeks which induced skeletal muscle insulin resistance. The Extenso...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-29 | PXD077541 | Pride
Mouse skeletal muscle Insulin resistance 
ProteomicsCysteine Redox proteomics of PDIA6 over-expressing skeletal muscle
To investigate the role of PDIA6 on changes to specific cysteine residues with altered redox status and insulin senstivity, we overexpressed either GFP control or FLAG-PDIA6 throughout the musculature of 4-day old male C57BL/6J mice via intraperitoneal injection with MyoAAV (Fig. 5F). At 8 weeks of ...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-29 | PXD075204 | Pride
Pdia6 Iodo-tmt 
MetabolomicsImpact of acute lymphoblastic leukemia induction therapy: findings from metabolomics on non-fasted plasma samples from a biorepository

INTRODUCTION: Acute lymphoblastic leukemia (ALL) is among the most common cancers in children. With improvements in combination chemotherapy regimens, the overall survival has increased to over 90%. However, the current challenge is to mitigate adverse events resulting from the c...

2021-08-12 | MTBLS2394 | MetaboLights
UnknownRisk Algorithm Using Serial Biomarker Measurements Doubles the Number of Screen-Detected Cancers Compared With a Single-Threshold Rule in the United Kingdom Collaborative Trial of Ovarian Cancer Screening.
Not available
S-EPMC4463475 | biostudies-literature
UnknownR1507, a monoclonal antibody to the insulin-like growth factor 1 receptor, in patients with recurrent or refractory Ewing sarcoma family of tumors: results of a phase II Sarcoma Alliance for Research through Collaboration study.
Not available
S-EPMC3236654 | biostudies-literature
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