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ProteomicsLipid Scrambling Pathways in the Sec61 Translocon Complex
Maintenance of cellular homeostasis and functionality requires rapid translocation of newly synthesized lipids across the membrane leaflets of the endoplasmic reticulum (ER) where majority of cellular lipid biosynthesis takes place. This process is facilitated without the need for ATP by specific me...
ORGANISM(S): Ovis canadensis sierrae 
2025-05-26 | PXD062310 | Pride
Translocon complex Sec61 
ProteomicsMolecular view of ER membrane remodeling by the Sec61/TRAP translocon
Cross-linking mass spectrometry of the sheep Sec61-TRAP complex
ORGANISM(S): Ovis Aries (ncbitaxon:9940) 
MSV000090438 | MassIVE
ProteomicsSND3 is the membrane insertase within a distinct SEC61 translocon complex
During the biogenesis of most eukaryotic integral membrane proteins (IMPs), transmembrane domains are inserted into the endoplasmic reticulum membrane by a dedicated insertase or the SEC61 translocon. The SRP-independent (SND) pathway is the least understood route into the membrane, despite catering...
ORGANISM(S): Chaetomium thermophilum 
2025-09-24 | PXD060914 | Pride
Proteomics Multipass translocon Membrane insertase Snd3 
UnknownComplexity and Specificity of Sec61-Channelopathies: Human Diseases Affecting Gating of the Sec61 Complex.
Not available
S-EPMC8147068 | biostudies-literature
ProteomicsA novel translocon for biogenesis of multi-pass membrane proteins
A novel 370 kDa translocon comprising Sec61 and five accessory factors acting co-translationally with ribosomes to fold and insert multi-pass membrane proteins was identified, purified and analyzed structurally by single particle cryo-EM and cross-linking mass spectrometry. The purified ribosome-tr...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-07-08 | MSV000084065 | MassIVE
UnknownLipid Scrambling Pathways in the Sec61 Translocon Complex.
Not available
S-EPMC12082634 | biostudies-literature
UnknownStructure of the mammalian ribosome-Sec61 complex to 3.4 A resolution.
Not available
S-EPMC4081569 | biostudies-literature
ProteomicsSubstrates of human TRAP complex
While the Sec61-complex in the membrane of the human endoplasmic reticulum facilitates translocation of all precursor polypeptides with amino-terminal signal peptides or transmembrane helices, the Sec61-associated translocon-associated protein (TRAP)-complex supports translocation of only a subset o...
ORGANISM(S): Homo sapiens (Human) 
2018-08-09 | PXD008178 | Pride
Sec61 complex Ms Hela cells Er protein import Trap complex 
UnknownThe Sec61/SecY complex is inherently deficient in translocating intrinsically disordered proteins.
Not available
S-EPMC5766967 | biostudies-literature
UnknownStability and function of the Sec61 translocation complex depends on the Sss1p tail-anchor sequence.
Not available
S-EPMC3095691 | biostudies-literature
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