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ProteomicsIgA deglycosylation to identify glycosylation sites
In order to provide information on the peptide sequence of the IgA glycopeptides, a proteomics analysis was run on LC-MS/MS data of N-glycosidase F-digested IgA samples, in which the N-glycans had been released. The samples included IgA (isolated) from: 1) the saliva samples from two healthy donors,...
ORGANISM(S): Homo sapiens (Human) 
2018-11-09 | PXD011228 | Pride
Iga Secretory iga Plasma Colostrum Saliva 
GenomicsNext-Generation Sequencing of sgRNA spacer sequences from a CRISPRi library screen of the Salmonella enterica serovar Typhimurium 14028s genome in response to repeated monoclonal IgA treatment
For this study, we implemented the anti-lipopolysaccharide monoclonal IgA Sal4 in a genome-wide CRISPR interference (CRISPRi) screen to identify genes that modulate the extent of agglutination of Salmonella enterica serovar Typhimurium (STm) in response to antibody exposure. We leveraged our recentl...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2025-02-16 | E-MTAB-14834 | biostudies-arrayexpress
ProteomicsDimeric IgA specifically disables intracellular mutated oncodrivers
Despite their long half-life, therapeutic antibodies are considered ineffective against intracellular antigens due to their perceived inability to penetrate epithelial cells. Using recombinant antibodies targeting common mutations in oncogenes, we show that dimeric IgA, but not the same antibody on ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD042914 | Pride
Transcytosis Cancer Therapeutic antibodies Immunoglobulin a 
ProteomicsIgA transcytosis and tumor antigen recognition govern anti-tumor immunity in ovarian cancer
Although most ovarian cancers show prognostically relevant activated T-cell infiltrates, response rates to immune checkpoint inhibitors are very modest4. Memory B-cell and plasma cell infiltrates have been associated with better outcome in ovarian cancer, but the nature and functional relevance of t...
ORGANISM(S): Homo sapiens (Human) 
2020-12-01 | PXD018079 | Pride
Ovarian cancer Prm Immunoglobulin a Transcytosis Lc-ms/ms Immunotherapy 
GenomicsSecretory IgA dysfunction underlies poor prognosis in Fusobacterium-infected colorectal cancer
Secretory IgA dysfunction underlies poor prognosis in Fusobacterium-infected colorectal cancer
PRJNA1142424 | ENA
TranscriptomicsSecretory Antibodies in Breast Milk Promote Long-Term Intestinal Homeostasis by Regulating the Gut Microbiota and Host Gene Expression.
Maintenance of intestinal homeostasis requires a healthy relationship between the commensal gut microbiota and the host immune system. Breast milk supplies the first source of antigen-specific immune protection in the gastrointestinal tract of suckling mammals, in the form of secretory immunoglobuli...
ORGANISM(S): Mus musculus 
2014-01-25 | E-GEOD-54371 | biostudies-arrayexpress
GenomicsSecretory IgA binding to FCRL3 triggers shared inflammatory cytokine secretion by human regulatory T cells and effector T cells
Secretory IgA binding to FCRL3 triggers shared inflammatory cytokine secretion by human regulatory T cells and effector T cells
PRJNA1160252 | ENA
GenomicsSecretory IgA enhances GI tract B cells priming and systemic IgG responses against commensal bacteria
Secretory IgA enhances GI tract B cells priming and systemic IgG responses against commensal bacteria
PRJEB34152 | ENA
TranscriptomicsSecretory IgA binding to FCRL3 triggers shared inflammatory cytokine secretion by human regulatory T cells and effector T cells
Several human lymphocyte subsets express the novel secretory IgA receptor FCRL3. Secretory IgA binding to FCRL3 mAb diminishes the inhibitory capacity of regulatory T cells and promotes a Th17-like phenotype. Here we report that in CD4+ regulatory T cells and CD8+ terminal effector T cells secretory...
ORGANISM(S): Homo sapiens 
2025-04-07 | GSE277028 | GEO
GenomicsSecretory IgA dysfunction underlies poor prognosis in Fusobacterium-infected colorectal cancer [normal colon tissue]
Secretory IgA dysfunction underlies poor prognosis in Fusobacterium-infected colorectal cancer [normal colon tissue]
PRJNA1220078 | ENA
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