Sort   by:  
 Page size 
GenomicsMitochondria-lysosome coupling contributes to lysosome acidification and aging
Mitochondria-lysosome coupling contributes to lysosome acidification and aging
PRJNA1240233 | ENA
UnknownSecretory autophagy during lysosome inhibition (SALI).
Not available
S-EPMC9542525 | biostudies-literature
TranscriptomicsSpatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes
Protein synthesis and autophagic degradation are regulated in an opposite manner by mammalian target of rapamycin (mTOR), whereas under certain conditions it would be beneficial if they occured in unison to handle rapid protein turnover. We observed a distinct cellular compartment at the trans-side ...
ORGANISM(S): Homo sapiens 
2011-05-04 | E-GEOD-28464 | biostudies-arrayexpress
ProteomicsMouse osteoclast homogenates nLC-ESI-MS/MS - WT vs Slc37a2 KO
To survey the proteomic differences between WT and Slc37a2 knockout osteoclasts at the whole cell and secretory lysosome levels, we used superparamagnetic iron oxide nanoparticles (SPIONs) to enrich for these endo-lysosomal-related organelles from murine osteoclast cultures. Briefly, large scale mur...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-25 | PXD037910 | Pride
Lysosome Lro Mouse Spion Osteoclast Secretory lysosome 
ProteomicsMouse osteoclast secretory lysosomes nLC-ESI-MS/MS
To survey the proteome of osteoclast secretory lysosomes, we used superparamagnetic iron oxide nanoparticles (SPIONs) to enrich for these endo-lysosomal-related organelles from murine osteoclast cultures. Briefly, large scale murine bone marrow monocyte (BMM)-derived osteoclast cultures were ‘pulsed...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-25 | PXD037006 | Pride
Lysosome Lro Mouse Spion Osteoclast Secretory lysosome 
ProteomicsMouse osteoclast secretory lysosomes nLC-ESI-MS/MS - WT vs Slc37a2 KO
To survey the proteome of osteoclast secretory lysosomes, we used superparamagnetic iron oxide nanoparticles (SPIONs) to enrich for these endo-lysosomal-related organelles from murine osteoclast cultures. Briefly, large scale murine bone marrow monocyte (BMM)-derived osteoclast cultures were ‘pulsed...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-25 | PXD037813 | Pride
Lysosome Lro Mouse Spion Osteoclast Secretory lysosome 
UnknownEssential Role of the a3 Isoform of V-ATPase in Secretory Lysosome Trafficking via Rab7 Recruitment.
Not available
S-EPMC5928161 | biostudies-literature
UnknownDisruption of the Man-6-P targeting pathway in mice impairs osteoclast secretory lysosome biogenesis.
Not available
S-EPMC3115509 | biostudies-literature
UnknownRouting of the RAB6 secretory pathway towards the lysosome related organelle of melanocytes.
Not available
S-EPMC5474736 | biostudies-literature
TranscriptomicsMitochondria-lysosome coupling contributes to lysosome acidification and aging
Nearly all cellular processes are pH dependent. The acidic pH inside the lysosome (vacuole in yeast) is essential for cellular content degradation, signaling, and autophagy. Defect in lysosome/vacuole acidification is a conserved hallmark of aging and age-related diseases. Traditionally, lysosome/va...
ORGANISM(S): Homo sapiens 
2026-03-20 | GSE292573 | GEO
Sort   by:  
 Page size