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ProteomicsThe Q Exactive HF, a Benchtop Mass Spectrometer with a Pre-filter, High Performance Quadrupole and an Ultra-High Field Orbitrap Analyzer
The quadrupole Orbitrap mass spectrometer (Q Exactive) has made a powerful proteomics instrument available in a benchtop format. It significantly boosted analyzable proteins per hour and has now evolved into a proteomics analysis workhorse for many laboratories. Here we describe the Q Exactive Plus ...
ORGANISM(S): Homo sapiens (Human) 
2014-11-10 | PXD001203 | Pride
Segmented quadrupole Q exactive hf Orbitrap ultra-high field Q exactive plus Quadrupole pre-filter Shotgun proteomics 
ProteomicsThe Q Exactive HF, a Benchtop Mass Spectrometer with a Pre-filter, High Performance Quadrupole and an Ultra-High Field Orbitrap Analyzer
The quadrupole Orbitrap mass spectrometer (Q Exactive) has made a powerful proteomics instrument available in a benchtop format. It significantly boosted analyzable proteins per hour and has now evolved into a proteomics analysis workhorse for many laboratories. Here we describe the Q Exactive Plus ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080865 | MassIVE
ProteomicsmsSIM for single-cell proteomic analysis
We report the development of the spectral library-based multiplex segmented Selected Ion Monitoring (SLB-msSIM) method, a novel approach that significantly improves sensitivity and robustness for single-cell analysis. Single-cell MS data is acquired using the msSIM technique, which sequentially appl...
ORGANISM(S): Homo sapiens (Human) 
2025-10-13 | PXD055915 | Pride
Selected ion monitoring Single-cell proteomics Cancer cell heterogeneity 
UnknownImproved segmented-scan spectral stitching for stable isotope resolved metabolomics (SIRM) by ultra-high-resolution Fourier transform mass spectrometry.
Not available
S-EPMC7153561 | biostudies-literature
UnknownThe Q Exactive HF, a Benchtop mass spectrometer with a pre-filter, high-performance quadrupole and an ultra-high-field Orbitrap analyzer.
Not available
S-EPMC4256516 | biostudies-literature
UnknownSLB-msSIM: A Spectral Library-Based Multiplex Segmented SIM Platform for Single-Cell Proteomic Analysis.
Not available
S-EPMC12491930 | biostudies-literature
ProteomicsProteome Dataset for Adult-derived Mouse Microglia
We report methods development for quantitative proteomic analysis of samples with limited number of cells. The improvements include suspension trapping (S-Trap) for sample processing, longer analytical column length (75cm), and a segmented data dependent acquisition approach. The modified approach w...
ORGANISM(S): Mus musculus (Mouse) 
2019-04-18 | PXD012006 | Pride
Neuroinflammation Img cells Proteomics Mass spectrometry Microglia Dataset brief Glia 
ProteomicsH.sapiens - Cell line, SC (Scheltemaetal,molcellproteomics,2014)
abundance based on Spectral counting, Interaction consistency score: 19.1, Coverage: 27
ORGANISM(S): 9606 
2014-00-00 | 4132152676 | PAXDB
ProteomicsIon mobility fractionation coupled to PASEF for enhanced proteome coverage
Data provided report the use of trapped ion mobility spectrometry (TIMS) to fractionate ions in the gas phase based on their ion mobility (V⋅s/cm2) followed by parallel accumulation serial fragmentation (PASEF) in a quadrupole time-of-flight instrument. TIMS fractionation coupled to DDA-PASEF allowe...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD033129 | Pride
Timstof pro Pasef Dia Segmented Tims fractionation Fractionation Optimized Deep coverage Dda Ion mobility 
ProteomicsProteomic analysis of alcohol and LPS-treated primary mouse microglia
Microglia, the resident immune cells of the brain, can exhibit a broad range of activation phenotypes, many of which have been implicated in several diseases and disorders of the central nervous system including alcohol use disorders and disorders. By utilizing a method optimized for sensitive and ...
ORGANISM(S): Mus musculus (Mouse) 
2020-04-07 | PXD014466 | Pride
Lps Neuroinflammation Ethanol Alcohol Microglia Glia 
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