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ProteomicsSemaphorin 5A modulates focal adhesion pathway and lamellipodia formation in melanoma
Introduction Metastatic potential and rising incidence make cutaneous melanoma a major health concern worldwide. Although the therapies currently in use have proven effective, their use is limited by side effects arising and development of drug resistance. For this reason, re...
ORGANISM(S): Homo sapiens (Human) 
2025-12-01 | PXD065661 | Pride
Semaphorin 5a Melanoma Lamellipodia Focal adhesion 
TranscriptomicsPotentiation of regulatory T cell stability and function via a neuropilin-1:semaphorin-4a axis
Regulatory T cells (Treg) represent a critical immunoregulatory component of the immune system. The signals that maintain Treg stability and potentiate their function remain obscure. Here we show that the immune cell surface ligand semaphorin-4a (Sema4a) Sema treated and NRP1 knock outs were compare...
ORGANISM(S): Mus musculus 
2013-09-06 | E-GEOD-41185 | biostudies-arrayexpress
TranscriptomicsAnnexin A2 controls pancreatic cancer invasion and metastasis through a novel axon guidance pathway
The mechanisms involved in promoting metastasis of pancreatic ductal adenocarcinoma have yet to be elucidated. Here, we show that AnnexinA2 regulates the secretion of Semaphorin3D from pancreatic tumor cells allowing it to bind to its receptor PlexinD1 on the surface of the tumor cell, which induces...
ORGANISM(S): Mus musculus 
2015-09-03 | E-GEOD-62285 | biostudies-arrayexpress
TranscriptomicsmiR-124 acts through coREST to control the onset of Sema3A sensitivity in navigating retinal growth cones
During axon pathfinding, growth cones commonly exhibit changes in sensitivity to guidance cues that follow a strict timetable, even in the absence of pathway feedback, implicating cell-intrinsic regulation. Cellular timer mechanisms, however, are poorly understood. Here we have investigated microRNA...
ORGANISM(S): Xenopus laevis 
2011-12-12 | E-GEOD-33444 | biostudies-arrayexpress
UnknownEndothelial Semaphorin 3fb regulates Vegf pathway-mediated angiogenic sprouting.
Not available
S-EPMC8412281 | biostudies-literature
UnknownCRMP4-mediated fornix development involves Semaphorin-3E signaling pathway.
Not available
S-EPMC8683083 | biostudies-literature
UnknownSemaphorin 5A modulates focal adhesion pathway and lamellipodia formation in melanoma.
Not available
S-EPMC12659518 | biostudies-literature
GenomicsSemaphorin activates Hippo signaling to control cell growth
Semaphorin activates Hippo signaling to control cell growth
PRJNA580522 | ENA
UnknownSemaphorin 3C promotes de novo steroidogenesis in prostate cancer cells.
Not available
S-EPMC10692650 | biostudies-literature
ProteomicsPRM of DMXAA-treated Raw264.7 secretome
Raw264.7 cells were cultured in serum-free DMEM containing DMSO or DMXAA for 4 h, and the conditioned media were collected. The precipitated proteins were directly digested with trypsin/Lys-C mix. Three biological replicates of the samples were individually prepared and analyzed by targeted LC-MS/MS...
ORGANISM(S): Mus Musculus (mouse) 
2018-04-04 | PXD009170 | JPOST Repository
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