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ProteomicsHuman Jurkat T cells SENP1 immunoprecipitates LC-MS
Identification of peptides matching to LCK in SENP1 immunoprecipitates from Jurkat E6.1 T cells by mass spectrometry
ORGANISM(S): Homo sapiens (Human) 
2022-01-13 | PXD029720 | Pride
Human Senp1 Lc-ms Jurkat t cells 
ProteomicsSENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation
SENP1 deSUMOylates RIPK1 in TNF-R1 signaling complex (TNF-RSC), keeping RIPK1 in check. Loss of SENP1 leads to SUMOylation of RIPK1, which re-orchestrates TNF-RSC and modulates the ubiquitination patterns and activity of RIPK1.
ORGANISM(S): Mus Musculus 
2022-10-24 | PXD037648 |
GenomicsSENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation
SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation
PRJNA796501 | ENA
GenomicsThe role of Senp1 in regulating CD8+ T cells activation
The role of Senp1 in regulating CD8+ T cells activation
PRJNA1368475 | ENA
GenomicsCarfilzomib Suppresses SENP1 to Trigger Cardiotoxicity by DDX17 Destabilization
Carfilzomib Suppresses SENP1 to Trigger Cardiotoxicity by DDX17 Destabilization
PRJNA1144389 | ENA
GenomicsDownregulation of SENP1 impairs nuclear condensation of MEF2C and deteriorates ischemic cardiomyopathy
Downregulation of SENP1 impairs nuclear condensation of MEF2C and deteriorates ischemic cardiomyopathy
PRJNA1200582 | ENA
TranscriptomicsSENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation
The mechanism underlying RIPK1-driven cell death and inflammation, a key process in the progression of nonalcoholic steatohepatitis, remains unclear. Here we identified SENP1, a SUMO-specific protease, as a key endogenous inhibitor of RIPK1. SENP1 is progressively reduced in proportion to NASH sever...
ORGANISM(S): Mus musculus 
2022-10-20 | GSE193509 | GEO
GenomicsSENP1 Regulates Germinal Center B Cell Responses through PAX5-deSUMOylation mediated AID expression
SENP1 Regulates Germinal Center B Cell Responses through PAX5-deSUMOylation mediated AID expression
PRJNA943153 | ENA
TranscriptomicsThe role of Senp1 in regulating CD8+ T cells activation
To better understan the role of Senp1 in regulating CD8+ T cells activation, we performed a transcriptional analysis (RNA-seq) to compare gene expression patterns between wild type and Senp1-deficient naïve CD8+ T cells or activated by anti-CD3/CD28.
ORGANISM(S): Mus musculus 
2026-02-07 | GSE311022 | GEO
TranscriptomicsDownregulation of SENP1 impairs nuclear condensation of MEF2C and deteriorates ischemic cardiomyopathy
Ischemic cardiomyopathy (ICM) is characterized by the insufficient capacity of the heart to effectively pump blood, which ultimately contributes to heart failure (HF). In this study, the down regulation of SNEP1 is identified in the cardiomyocyte of ICM mouse models and in patients. The depletion of...
ORGANISM(S): Mus musculus 
2025-05-14 | GSE284743 | GEO
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