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ProteomicsIdentification of SENP8 interacting proteins by LC-MS/MS in mouse GC-1 cells
To identify the proteins that interact with SENP8 in GC-1 cells, immunocoprecipitation (IP) experiments were performed. The samples from these experiments were analyzed using LC-MS/MS and subject to Label-free quantification.
ORGANISM(S): Mus musculus (Mouse) 
2026-09-07 | PXD071924 | Pride
Gc-1 Senp8 Ip Lc-ms/ms 
GenomicsRNA Sequencing of Wild Type and SENP8+/- BMDM Transcriptomes after Treated with CD47-coated Beads
RNA Sequencing of Wild Type and SENP8+/- BMDM Transcriptomes after Treated with CD47-coated Beads
PRJNA820761 | ENA
TranscriptomicsRNA Sequencing of Wild Type and SENP8+/- BMDM Transcriptomes after Treated with CD47-coated Beads
Neddylation is coupled with tumor-cell survival by its well-characterized substrates Cullins. However, how neddylation impacts the tumor immune microenvironment is not clear. SENP8 deconjugates NEDD8 from non-Cullin targets to maintain the dynamic and reversible neddylation equilibrium. CD47 treated...
ORGANISM(S): Mus musculus 
2023-10-01 | GSE199585 | GEO
GenomicsBulk RNA-Seq of GC-1 cells transfected with si-NC, si-Senp8, or si-Stat1
Bulk RNA-Seq of GC-1 cells transfected with si-NC, si-Senp8, or si-Stat1
PRJEB105619 | ENA
UnknownThe molecular determinants of NEDD8 specific recognition by human SENP8.
Not available
S-EPMC3215745 | biostudies-literature
UnknownSENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function.
Not available
S-EPMC5419743 | biostudies-literature
TranscriptomicsBulk RNA-Seq of GC-1 cells transfected with si-NC, si-Senp8, or si-Stat1
RNA-Seq analyses were performed on GC-1 cells transfected with si-NC (control), si-Senp8, or si-Stat1, to study the regulatory networks between Senp8 and Stat1.
ORGANISM(S): Mus musculus 
2025-12-25 | E-MTAB-16423 | biostudies-arrayexpress
UnknownCentral role for endothelial human deneddylase-1/SENP8 in fine-tuning the vascular inflammatory response.
Not available
S-EPMC3529810 | biostudies-literature
ProteomicsSENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin- 1 RING ubiquitin ligase function
NEDD8 is a ubiquitin-like modifier most well-studied for its role in activating the largest family of ubiquitin E3 ligases, the cullin-RING ligases (CRLs). While many non-cullin neddylation substrates have been proposed over the years, validation of true NEDD8 targets has been challenging, as overex...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-13 | MSV000080917 | MassIVE
ProteomicsNEDD8 subtrates from NEDP1 knockout cells
The aim of the study was to identify proteins that are modified by NEDD8. The NEDD8 specific protease NEDP1/SENP8 was deleted from HEK 293 cells via Crispr/CAS9 gene editing to allow for the accumulation of NEDD8 modified proteins. Lysates from NEDP1 KO cells were then enriched via pulldown with a...
ORGANISM(S): Homo sapiens (Human) 
2019-02-20 | PXD011928 | Pride
Human Nedd8 Nedp1 Senp8 Hek 293 
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