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TranscriptomicsHuman Insulin Resistance and Thiazolidinedione-Mediated Insulin Sensitization
Cellular and tissue defects associated with insulin resistance are coincident with transcriptional abnormalities and are improved after insulin sensitization with thiazolidinedione (TZD) PPAR? ligands. We transcriptionally profiled 364 biopsies gathered from 72 human subjects harvested before and af...
ORGANISM(S): Homo sapiens 
2010-05-17 | E-GEOD-13070 | biostudies-arrayexpress
TranscriptomicsS-adenosylmethionine modifies cocaine-induced DNA methylation and increases locomotor sensitization in mice
The aim of the study was to investigate whether environmental factors like S-adenosylmethionine (SAM) via affecting epigenome could alter cocaine-induced gene expression and locomotor sensitization in mice. Using mouse nucleus accumbens (NAc) tissue, whole-genome gene expression profiling revealed t...
ORGANISM(S): Mus musculus 
2013-06-27 | E-GEOD-48365 | biostudies-arrayexpress
UnknownNew Horizons in Skin Sensitization Assessment of Complex Mixtures: The Use of New Approach Methodologies Beyond Regulatory Approaches.
Not available
S-EPMC12390330 | biostudies-literature
TranscriptomicsAplysia pleural Ganglia 1 Hour After Long-Term Sensitization Training
We used a custom-designed microarray and qPCR to characterize the rapid transcriptional response to long-term sensitization training in the marine mollusk Aplysia californica. Aplysia were exposed to repeated noxious shocks to one side of the body (4 ten-second shocks at 90mA, 30 min ISI), a proced...
ORGANISM(S): Aplysia californica 
2014-05-08 | E-GEOD-57458 | biostudies-arrayexpress
GenomicsMouse lung DC RNA-Seq after allergic sensitization
Mouse lung DC RNA-Seq after allergic sensitization
PRJNA630094 | ENA
TranscriptomicsEffect of allergen sensitization on gene expression in dendritic cells from neonates of asthmatic vs control mothers
This study aims to demonstrate the link between epigenome-wide methylation aberrations at birth and genomic transcriptional changes upon allergen sensitization that occur in the neonatal dendritic cells (DC) due to maternal asthma. In an in vivo model reproducing human epidemiology findings, materna...
ORGANISM(S): Mus musculus 
2013-06-01 | E-GEOD-44678 | biostudies-arrayexpress
TranscriptomicsSelective boosting of transcriptional and behavioral responses to drugs of abuse by histone deacetylase inhibition
Histone acetylation and other modifications of the chromatin are important regulators of gene expression and, consequently, may contribute to drug-induced behaviors and neuroplasticity. Previous studies have shown that a reduction on histone deacetylase (HDAC) activity results on the enhancement of ...
ORGANISM(S): Mus musculus 
2010-09-17 | E-GEOD-17731 | biostudies-arrayexpress
TranscriptomicsRNA-seq data of lung resident T-cells from mice following house dust mite (HDM) sensitisation and subsequent influenza virus challenge
This data is from a murine model established to study the lasting impact of allergic airway sensitization on subsequent anti-viral memory T cell responses and the ability to develop protective immunity to reinfection. Animals were either sensitised by exposure to HDM or PBS and then subsequently exp...
ORGANISM(S): Mus musculus 
2023-01-30 | E-MTAB-11116 | biostudies-arrayexpress
GenomicsAplysia Pleural Ganglia 7 Days After Long-Term Sensitization Training.
Aplysia Pleural Ganglia 7 Days After Long-Term Sensitization Training.
PRJNA1396645 | ENA
GenomicsSystems Biology of Allergic Sensitization to Olea europaea Pollen
Systems Biology of Allergic Sensitization to Olea europaea Pollen
PRJEB122644 | ENA
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