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ProteomicsYeast Serine palmitoyl transferase interaction proteomics
ALFA pulldowns of the Lcb1 subunit of the yeast serine palmitoyltransferase. Wt Lcb1 is compared to a mutant lacking the trans membrane helix 1 of Lcb1 and to control pulldowns lackingthe ALFA tag on Lcb1.
ORGANISM(S): Saccharomyces cerevisiae Saccharomyces cerevisiae (Baker's yeast) 
2024-09-12 | PXD048754 | Pride
Orm2 Sphingolipid Serine palmitoyl transferase Orm1 
UnknownUsing a biologically annotated library to analyze the anticancer mechanism of serine palmitoyl transferase (SPT) inhibitors.
Not available
S-EPMC5377399 | biostudies-literature
ProteomicsIdentification of distinct active pools of yeast serine palmitoyltransferase in sub-compartments of the ER.
Interaction proteomics of rewired serine palmitoyl transferase strains from Esch et al. 2023
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-12-01 | PXD047438 | Pride
Spt interaction proteomics 
UnknownIncreased expression of serine palmitoyl transferase and ORMDL3 polymorphism are associated with eosinophilic inflammation and airflow limitation in aspirin-exacerbated respiratory disease.
Not available
S-EPMC7544079 | biostudies-literature
UnknownThe serine palmitoyl transferase of plant pathogenic fungi: a promising new target for the development of novel crop protection solutions<sup>†</sup>.
Not available
S-EPMC12441766 | biostudies-literature
ProteomicsAn ERAD independent role for rhomboid pseudoprotease Dfm1 in mediating sphingolipid homeostasis
Nearly one-third of nascent proteins are initially targeted to the endoplasmic reticulum (ER) where they are correctly folded and assembled before being delivered to their final cellular destinations. To prevent the accumulation of misfolded membrane proteins, ER-associated-degradation (ERAD) remove...
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
MSV000090333 | MassIVE
Unknown1-Deoxysphinganine initiates adaptive responses to serine and glycine starvation in cancer cells via proteolysis of sphingosine kinase.
Not available
S-EPMC8953655 | biostudies-literature
TranscriptomicsEnhanced deoxysphingobase production in HSN1 results in sensory nerve toxicity through deficits in both cell autonomous and axoglial signalling, ameliorated by serine treatment
Hereditary sensory neuropathy type 1 (HSN1) is caused by mutations in either the SPTLC1 or SPTLC2 sub-units of the enzyme Serine Palmitoyl Transferase resulting in the production of Deoxyshingobases (DSBs). Exogenous DSBs are toxic when acutely applied to neurons however it’s unknown whether endogen...
ORGANISM(S): Homo sapiens 
2020-03-25 | GSE144208 | GEO
UnknownClinical and metabolic consequences of L-serine supplementation in hereditary sensory and autonomic neuropathy type 1C.
Not available
S-EPMC5701299 | biostudies-literature
GenomicsEnhanced deoxysphingobase production in HSN1 results in sensory nerve toxicity through deficits in both cell autonomous and axoglial signalling, ameliorated by serine treatment
Enhanced deoxysphingobase production in HSN1 results in sensory nerve toxicity through deficits in both cell autonomous and axoglial signalling, ameliorated by serine treatment
PRJNA603068 | ENA
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