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ProteomicsBenchmarking of mass spectrometry-based antibody repertoire profiling reveals extensive systematic biases
The serum antibody repertoire is crucial for long-term immune protection, holding significant immunological and biotechnological value. Bottom-up proteomics is the most widely used mass spectrometry (MS) technique for profiling the sequence diversity of serum antibodies. However, serum antibody bott...
ORGANISM(S): Homo sapiens (Human) 
2025-12-04 | PXD055846 | Pride
Serum antibody bottom-up proteomics (ab-seq) Ms Antibody sequencing Serum antibody repertoire 
ProteomicsBenchmarking and integrating human B-cell receptor genomic and antibody proteomic profiling
Antibodies are immune glycoproteins that represent a crucial part of the adaptive immune system as they mediate broad protection against viruses, bacteria, and cancer. Moreover, antibodies may serve as a unique source of information on past and current physiological and pathological events in the hu...
ORGANISM(S): Homo sapiens (Human) 
2024-06-04 | PXD046237 | Pride
Human Lc-msms Plasma Antibody 
ProteomicsIdentification of SARS-COV-2 specific antibodies from patient serum during the First Wave of the COVID-19 pandemic
Proteomic Ig-SEQ identification of SARS-COV-2 specific antibodies from serum of two convalescent patients during the first wave of the COVID-19 pandemic. Total IgG was isolated from serum, digested with IdeS protease to generate F(ab)2 fragments, and subjected to antigen affinity chromatography usin...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD046829 | Pride
Igg Human Ig-seq Serum antibody profiling Sars-cov-2 Orbitrap fusion lumos Lc-msms 
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