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ProteomicsHDX-MS of Immobilized Staph Enterotoxin B with Neutralizing Serum
Elucidating the interactions that drive antigen recognition is central to understanding antibody-based protection and is vital for the rational design of immunogens. Often, structural knowledge of epitopes targeted by antibodies is derived from isolated studies of monoclonal antibodies, for which nu...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-27 | PXD051156 | Pride
Hdx-ms Serum hdx Seb Immobilized hdx 
ProteomicsHDX of SEB and Neutralizing mAbs
Elucidating the interactions that drive antigen recognition is central to understanding antibody-based protection and is vital for the rational design of immunogens. Often, structural knowledge of epitopes targeted by antibodies is derived from isolated studies of monoclonal antibodies, for which nu...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-27 | PXD051141 | Pride
Hdx-ms Hydorgen deuterium exchange Seb 
UnknownDirect Mapping of Polyclonal Epitopes in Serum by HDX-MS.
Not available
S-EPMC11583827 | biostudies-literature
UnknownThe Conformational Changes of Bovine Serum Albumin at the Air/Water Interface: HDX-MS and Interfacial Rheology Analysis.
Not available
S-EPMC10137346 | biostudies-literature
UnknownHydrophilic Interaction Liquid Chromatography-Hydrogen/Deuterium Exchange-Mass Spectrometry (HILIC-HDX-MS) for Untargeted Metabolomics.
Not available
S-EPMC10932214 | biostudies-literature
ProteomicsStructure dynamics of ApoA-I amyloidogenic variants in small HDL increase their ability to mediate cholesterol efflux
Specific mutations in Apolipoprotein A-I (ApoA-I) of high-density lipoprotein (HDL) are responsible for a late-onset systemic amyloidosis. Carriers do not exhibit increased cardiovascular disease risk despite reduced levels of ApoA-I/ HDL-cholesterol. To explain this paradox, we show that the HDL pa...
ORGANISM(S): Homo sapiens (Human) 
2020-11-20 | PXD021266 | Pride
Hdx-ms Amyloidogenic apoa-i variants 
UnknownPro-calcifying analysis of uraemic serum from patients treated with medium cut-off membrane in a prospective, cross-over study.
Not available
S-EPMC8243281 | biostudies-literature
ProteomicsStructural basis for lipid binding and function by an evolutionally conserved protein, Serum Amyloid A
Serum amyloid A (SAA) is a plasma protein that transports lipids during inflammation. To explore SAA solution conformations and lipid binding mechanism, we used hydrogen-deuterium exchange mass spectrometry, lipoprotein reconstitution, sequence analysis and molecular dynamics simulations. Solution ...
ORGANISM(S): Mus musculus (Mouse) 
2020-02-17 | PXD016391 | Pride
Hydrogen-deuterium exchange mass spectrometry  molecular dynamics simulations  lipoprotein nanoparticle  intrinsically disordered protein  β-hairpin misfolding intermediate  inflammation and immunity 
UnknownEffects of a medium cut-off (Theranova®) dialyser on haemodialysis patients: a prospective, cross-over study.
Not available
S-EPMC7857781 | biostudies-literature
ProteomicsIn vitro reconstitution of Sgk3 activation by phosphatidylinositol-3-phosphate
Serum- and glucocorticoid-regulated kinase 3 (Sgk3) is activated by the phospholipid 19 phosphatidylinositol-3-phosphate (PI3P) downstream of growth factor signaling and 20 by Vps34-mediated PI3P production during autophagy. Upregulation of Sgk3 activity 21 has been linked to a number of human cance...
ORGANISM(S): Homo sapiens (Human) 
2021-09-22 | PXD025327 | Pride
Kinase Sgk3 Hdx-ms Pi3p 
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