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MetabolomicsMild cold exposure mitigates ischemic heart injury through indole-3-acetamide–AHR-mediated SMAD2 proteolysis

Ambient temperature profoundly influences organismal metabolism, physiology, and disease. While cold exposure is a well-recognized risk factor for the onset of myocardial infarction (MI), its impact on the injured heart after MI remains unexplored. Here,&nb...

2026-03-03 | MTBLS13965 | MetaboLights
MetabolomicsUntargeted Metabolomics Reveals Serum Metabolic Differences and Key Biomarkers Associated with Growth Traits in Male and Female Macrobrachium rosenbergii of Different Sizes

Macrobrachium rosenbergii is one of the most economically important crustaceans globally, but significant individual growth differences persist even under the same genetic background and rearing conditions, limiting the sustainability of its aquaculture industry. Metabolomics, as a powerful tool ...

2025-11-21 | MTBLS13361 | MetaboLights
TranscriptomicsBuffering and proteolysis are induced upon segmental haploidy in Drosophila melanogaster.
Aneuploidy, i.e., variation in the number of individual chromosomes (chromosomal aneuploidy) or chromosome segment (segmental aneuploidy) is associated with developmental abnormalities and reduced fitness in all species examined, is the leading cause of miscarriages and mental retardations and a hal...
ORGANISM(S): Drosophila melanogaster 
2012-04-04 | E-GEOD-34400 | biostudies-arrayexpress
ProteomicsA new method for differential proteomic analysis utilizing native MS-electropherograms: a comparison between plasma and serum proteins by combining native PAGE, whole-gel slicing and quantitative LC-MS/MS
MS identification has long been used for PAGE-separated protein bands, but global and systematic quantitation utilizing MS after PAGE has remained rare and not been reported for native PAGE. Here we reported on a new method combining native PAGE, whole-gel slicing and quantitative LC-MS/MS aiming c...
ORGANISM(S): Homo sapiens (Human) 
2017-09-08 | PXD006773 | Pride
Gel slicing Quantitative lc-ms/ms Native ms-electropherogram Native 1d-page Human plasma and serum Differential proteomic analysis 
ProteomicsMALDI-MS Profiling of Intact Blood Proteins without the Need for Freezing - Dried Serum Spots as Future Clinical Tools for Patient Screening
To open new ways for MALDI-MS-based patient screening, blood serum is the most preferred specimen because of its richness in patho-physiological information and due to ease of collection. To overcome deleterious freeze / thaw cycles and to reduce high costs for shipping and storage, we sought to dev...
ORGANISM(S): Homo sapiens (Human) 
2021-05-20 | PXD024669 | Pride
Intact serum protein analysis Maldi-ms profiling Fast frozen serum Serum proteolysis analysis Dried serum spots 
TranscriptomicsGene expression in canine uterine bacterial infection
The study was undertaken to analyze the effect of canine uterine bacterial infection (Pyometra) on local gene expression patterns in the uteri. The results show profound upregulation of various expected genes related to both the innate and innate immune system. In addition, there was a marked upregu...
ORGANISM(S): Canis lupus familiaris 
2010-08-20 | E-GEOD-17878 | biostudies-arrayexpress
ProteomicsQuantitative proteomic analysis of serum-purified exosomes reveals putative pre-eclampsia associated biomarkers
The high incidence of pre-eclampsia, affecting 5-10% of pregnancies, makes it a major health problem. Early detection of pre-eclampsia, before the appearance of the first clinical symptoms, is therefore an urgent need, since it would allow the early intervention. Identification of plasma/serum bioma...
ORGANISM(S): Homo sapiens (Human) 
2022-02-21 | PXD025308 | Pride
Pre-eclampsia Exosome Proteomics Pregnancy Mass spectrometry Plasma Serum Biomarkers Cohort studies 
ProteomicsShotgun analysis of serum proteome on Schistosoma mansoni infection
This project is a Shotgun analysis of serum proteome on Schistosoma mansoni infection
ORGANISM(S): Mus musculus (Mouse) 
2022-08-18 | PXD031974 | Pride
Schistosoma mansoni Shotgun Serum proteome 
ProteomicsPosition-specific N- and O-glycosylation of the reactive centre loop impacts neutrophil elastase-mediated proteolysis of corticosteroid-binding globulin
Corticosteroid-binding globulin (CBG) delivers anti-inflammatory cortisol to inflamed tissues through the proteolytic cleavage of an exposed reactive centre loop (RCL) by neutrophil elastase (NE). We previously demonstrated that RCL-localised Asn347-linked N-glycans impact NE proteolysis, but a comp...
ORGANISM(S): Homo sapiens (Human) 
2023-12-05 | PXD046405 | Pride
Glycosylation O-glycosylation Corticosteroid-binding globulin Cortisol N-glycosylation Proteolysis Reactive centre loop Neutrophil elastase 
ProteomicsGlycoproteome Profiling of Human Serum for Hepatocellular Carcinoma Biomarker Discovery
Hepatocellular carcinoma (HCC) typically develops on a cirrhotic background, where conventional serum biomarkers such as alpha-fetoprotein (AFP) provide inconsistent performance. We implemented an integrated serum intact glycoproteomics strategy that profiles N-linked and O-linked glycopeptides in p...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD075370 | Pride
Nano-lc-ms/ms Liver cancer Glycoproteomics Human serum Biomarker 
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