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ProteomicsDysfunction of a SET3C-like complex underlies a family of related neurological disorders
TBLR1, a subunit of the NCoR corepressor complex, is mutated in a range of neurodevelopmental disorders that only partially align symptomatically with those caused by mutations in its binding partner, MeCP2. In a search for novel TBLR1-binding partners, we identified ANKRD11 and SETD5 – mutations in...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-01 | PXD063846 | Pride
Human Tblr1 Neurological disorders Ankrd11 Setd5 Set3c 
ProteomicsDysfunction of a SET3C-like complex underlies a family of related neurological disorders
TBLR1, a subunit of the NCoR corepressor complex, is mutated in a range of neurodevelopmental disorders that only partially align symptomatically with those caused by mutations in its binding partner, MeCP2. In a search for novel TBLR1-binding partners, we identified ANKRD11 and SETD5 – mutations in...
ORGANISM(S): Homo sapiens (Human) 
2026-05-01 | PXD077916 | Pride
Dia. Tblr1 Mecp2 Set3c-like complex Ankrd11 Setd5 Neurodevelopmental disorders Dda 
TranscriptomicsTranscription profiling by tiling array of yeast undergoing a series of carbon source shifts to discern how Set3C affects gene expression
Set3 complex (Set3C) binds histone H3 dimethylated at lysine 4 (H3K4me2) to mediate deacetylation of histones in 5Õ transcribed regions. To discern how Set3C affects gene expression, genome-wide transcription was analyzed in yeast undergoing a series of carbon source shifts. Deleting SET3 primarily ...
ORGANISM(S): Saccharomyces cerevisiae 
2012-09-05 | E-MTAB-1250 | biostudies-arrayexpress
GenomicsUnraveling the Mechanism of Thermotolerance in Cryptococcus neoformans by Set3C Complex
Unraveling the Mechanism of Thermotolerance in Cryptococcus neoformans by Set3C Complex
PRJNA1011339 | ENA
GenomicsTranscription Profiles of [ESI+] and Set3C loss of function
Transcription Profiles of [ESI+] and Set3C loss of function
PRJNA528474 | ENA
TranscriptomicsGene deletion expression profiles of yeast chromatin modifiers
Packaging of DNA into chromatin has a profound impact on gene expression. To understand how changes in chromatin influence transcription, we analyzed 165 mutants of chromatin machinery components in Saccharomyces cerevisiae. mRNA expression patterns change in 80% of mutants, always with specific eff...
ORGANISM(S): Saccharomyces cerevisiae 
2011-05-23 | E-GEOD-25909 | biostudies-arrayexpress
TranscriptomicsUnraveling the Mechanism of Thermotolerance in Cryptococcus neoformans by Set3C Complex
Thermotolerance, a key factor essential for the virulence of pathogenic fungi including Cryptococcus neoformans, remains largely unexplored in terms of its underlying mechanism. In this study, our findings demonstrate that Set3C, a widely distributed and conserved histone deacetylase complex, is req...
ORGANISM(S): Cryptococcus neoformans 
2023-09-05 | GSE242109 | GEO
UnknownThe S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program.
Not available
S-EPMC312828 | biostudies-literature
UnknownSet3 HDAC mediates effects of overlapping noncoding transcription on gene induction kinetics.
Not available
S-EPMC3461055 | biostudies-literature
UnknownStructural and functional analysis of the SET3 histone deacetylase complex.
Not available
S-EPMC8900736 | biostudies-literature
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