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TranscriptomicsExpression data from human SGBS adipocytes under hypoxic conditions
Hypoxia in adipose tissue is suggested to be involved in the development of a chronic mild inflammation, which in obesity can further lead to insulin-resistance. The effect of hypoxia on gene expression in adipocytes seems to play a central role in this inflammatory response observed in obesity. How...
ORGANISM(S): Homo sapiens 
2011-04-14 | E-GEOD-28603 | biostudies-arrayexpress
ProteomicsProteome dynamics during differentiation of SGBS adipocytes
Here, we identified temporal dynamics in the proteome during adipocyte differentiation of the human SGBS cells, applying untargeted proteomics. Samples were taken at initiation of differentiation, at an intermediate and terminal time point.
ORGANISM(S): Homo sapiens (Human) 
2024-06-13 | PXD045767 | Pride
Adipogenesis Adipocytes Proteome Temporal dynamics Sgbs 
TranscriptomicsIn situ promoter capture Hi-C data of differentiated SGBS human preadipocytes (days 0, 2, 8 and 16 of differentiation to adipocytes) and iPSC-derived hypothalamic neurons (days 12, 16 and 27 of differentiation)
Human SGBS preadipocytes were differentiated into adipocytes, and human iPSCs were differentiated into hypothalamic neurons. Cells were collected for in situ promoter capture Hi-C [PMID: 29988018] at several differentiation stages. The differentiations were performed in one biological replicate, wit...
ORGANISM(S): Homo sapiens 
2021-05-29 | E-MTAB-10488 | biostudies-arrayexpress
ProteomicsAcetylome dynamics during differentiation of SGBS adipocytes
Here, we identified temporal dynamics of the acetylome during adipocyte differentiation in human SGBS cells, applying untargeted proteomics in combination with immunoaffinity purification of acetylated peptides. Samples were taken at initiation of differentiation, at an intermediate and terminal tim...
ORGANISM(S): Homo sapiens (Human) 
2024-06-13 | PXD045768 | Pride
Adipogenesis Acetylome Adipocytes Temporal dynamics Sgbs 
TranscriptomicsOpen chromatin profiling (ATAC-seq) of SGBS human preadipocytes (days 0, 2, 8 and 16 of differentiation to adipocytes) and iPSC-derived hypothalamic neurons (days 12, 16 and 27 of differentiation)
Human SGBS preadipocytes were differentiated into adipocytes, and human iPSCs were differentiated into hypothalamic neurons. Cells were collected for ATAC-seq at several differentiation stages. The differentiations were performed in one biological replicate, with two technical replicates (different ...
ORGANISM(S): Homo sapiens 
2021-05-22 | E-MTAB-10462 | biostudies-arrayexpress
ProteomicsPhosphoproteome dynamics during differentiation of SGBS adipocytes
Here, we identified temporal dynamics of the phosphoproteome during adipocyte differentiation in the human SGBS cells, applying untargeted proteomics in combination with enrichment strategies for phosphorylated peptides. Samples were taken at initiation of differentiation, at an intermediate and ter...
ORGANISM(S): Homo sapiens (Human) 
2024-06-13 | PXD045770 | Pride
Adipogenesis Adipocytes Phosphoproteome Temporal dynamics Sgbs 
TranscriptomicsGene expression profiling (RNA-seq) of SGBS human preadipocytes (days 0, 2, 8 and 16 of differentiation to adipocytes) and iPSC-derived hypothalamic neurons (days 12, 16 and 27 of differentiation)
Human SGBS preadipocytes were differentiated into adipocytes, and human iPSCs were differentiated into hypothalamic neurons. Cells were collected for RNA-seq at several differentiation stages. The differentiations were performed in one biological replicate, with three technical replicates (different...
ORGANISM(S): Homo sapiens 
2021-05-22 | E-MTAB-10461 | biostudies-arrayexpress
ProteomicsTMT-based proteome and phosphoproteome profiling of control and GPR146 knockdown SGBS cells
This dataset contains quantitative proteome and phosphoproteome profiles of control and GPR146 knockdown SGBS human preadipocyte cells. Cells were processed for tandem mass tag (TMT)–based multiplexed quantitative mass spectrometry, with parallel analysis of total proteome input samples and TiO2-enr...
ORGANISM(S): Homo sapiens (Human) 
2026-02-19 | PXD074087 | Pride
Phosphoproteomics Gpr146 Sgbs cells Orbitrap Tmt6plex Lc-ms/ms 
GenomicsPromoter capture-C of differentiated SGBS cells
Promoter capture-C of differentiated SGBS cells
PRJEB30484 | ENA
TranscriptomicsHigh throughput analysis of three human adipose cell lines PAZ6, SGBS and SW872
We report molecular characterization of human brown and white adipocytes. We showed that PAZ6 and SW872 cells exhibit classical molecular and phenotypic markers of brown and white adipocytes, respectively. However, SGBS cells presented a versatile phenotype of adipocyte Sequencing of three human adi...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-GEOD-63190 | biostudies-arrayexpress
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