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TranscriptomicsTranscription profiling of neuronal differentiation in two subtypes of SH-SY5Y
Background: SH-SY5Y cells exhibit a neuronal phenotype when treated with all-trans retinoic acid (RA), but the molecular mechanism of activation in the signaling pathway mediated by phosphatidylinositol 3-kinase (PI3K) is not sufficiently understood. To shed new light on the mechanism, we comprehens...
ORGANISM(S): Homo sapiens 
2009-09-04 | E-GEOD-9169 | biostudies-arrayexpress
ProteomicsTemporal Quantitative Proteomic Profiling of SH-SY5Y and IMR-32 Neuroblastoma Cells During All-trans Retinoic Acid-Induced Neuronal Differentiation
The human neuroblastoma cell lines SH-SY5Y and IMR-32 can be differentiated into neuron-like phenotypes through treatment with all-trans retinoic acid (ATRA). After differentiation, these cell lines are extensively utilized as in vitro models to study various aspects of neuronal cell biology. Howeve...
ORGANISM(S): Homo sapiens (Human) 
2024-01-24 | PXD046900 | Pride
Sh-sy5y Imr-32 Neuronal differentiation Tmt Proteomics 
ProteomicsTemporal Quantitative Phosphoproteomic Profiling of SH-SY5Y and IMR-32 Neuroblastoma Cells During All-trans Retinoic Acid-Induced Neuronal Differentiation
The human neuroblastoma cell lines SH-SY5Y and IMR-32 can be differentiated into neuron-like phenotypes through treatment with all-trans retinoic acid (ATRA). After differentiation, these cell lines are extensively utilized as in vitro models to study various aspects of neuronal cell biology. Howeve...
ORGANISM(S): Homo sapiens (Human) 
2024-01-24 | PXD046871 | Pride
Phosphoproteomics Sh-sy5y Imr-32 Neuronal differentiation Tmt 
ProteomicsSystematic evaluation of morphological and molecular changes in SH-SY5Y cells induced by common differentiation protocols with a particular focus on the abundance of neuronal subtypes
The SH-SY5Y cell line is a triple-cloned subline of SK-N-SH cells that were originally isolated in the early 1970s from a bone marrow biopsy of a four-year-old female patient suffering from neuroblastoma. Since then, this cell line has been used as one of the major cell culture models in neuroscienc...
ORGANISM(S): Homo sapiens (Human) 
2025-11-24 | PXD064335 | Pride
Sh-sy5y Proteomics Mass spectrometry Differentiation Neuronal subtype 
TranscriptomicsGene expression profile after SYT9 re-expression during differentiation of CSB-KD SH-SY5Y cells
CSB-depletion induced SH-SY5Y differentiation defects can be partially rescued by re-expression of SYT9 gene. This study characterizes the transcriptome signatures upon SYT9 re-expression in CSB-KD SH-SY5Y cells after RA treatment. The Nimblegen human 12 x 135K gene expression array was used to char...
ORGANISM(S): Homo sapiens 
2016-02-29 | E-GEOD-58072 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human differentiated vs. undifferentiated SH-SY5Y cells transfected with a MeCP2 (transcriptional repressor) decoy to investigate the neurodevelopmental disorder Rett syndrome
Rett syndrome (RTT) is an X-linked dominant neurodevelopmental disorder caused by mutations in MECP2, encoding methyl-CpG-binding protein 2. MeCP2 is a transcriptional repressor elevated in mature neurons and is predicted to be required for neuronal maturation by regulating multiple target genes. Id...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-4600 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of gene expression profiles in human neuroblastoma SH-SY5Y cells exposed to norephedrine
To reveal the molecular mechanism underling necrotic neuronal cell death caused by norephedrine, we examined alteration of gene expression profile during norephedrine exposure in human neuroblastoma SH-SY5Y cells. The alteration of gene expression during norephedrine exposure (3 mM, 0,2 and 6 hours)...
ORGANISM(S): Homo sapiens 
2015-04-08 | E-GEOD-67643 | biostudies-arrayexpress
GenomicsLarge-scale methylation domains mark a functional subset of neuronally expressed genes
DNA methylation is essential for embryonic and neuronal differentiation, but the function of most genomic DNA methylation marks are poorly understood. Generally the human genome is highly methylated (>70%) except for CpG islands and gene promoters. However, it was recently shown that the IMR90 human...
ORGANISM(S): Homo sapiens 
2011-06-23 | E-GEOD-25930 | biostudies-arrayexpress
TranscriptomicsExpression Data form parental vs. TAE684 resistant SH-SY5Y neuroblastoma cells
The crizotinib–resistant ALKF1174L mutation arises de novo in neuroblastoma (NB) and is acquired in ALK translocation-driven cancers, lending impetus to the development of novel ALK inhibitors with different modes of action. The diaminopyrimidine TAE684 and its derivative ceritinib (LDK378), which...
ORGANISM(S): Homo sapiens 
2015-11-21 | E-GEOD-73292 | biostudies-arrayexpress
ProteomicsQuantitative proteomics study on RA+BDNF induced SHSY5Y differentiation
A detailed quantitative proteomic study upon neuronal differentiation of SHSY5Y by sequential exposure of RA+BDNF
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-10-22 | MSV000088256 | MassIVE
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