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TranscriptomicsTranscription profiling of S. cerevisiae mRNA abundance following oxidative stress and DNA damage stress
We subjected yeast to two stresses, oxidative stress, which under current settings induces a fast and transient response in mRNA abundance, and DNA damage, which triggers a slow enduring response. Using microarrays we performed a conventional quantification of change in mRNA abundance. Experiment O...
ORGANISM(S): Saccharomyces cerevisiae 
2008-10-26 | E-GEOD-12220 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. cerevisiae mRNAs following oxidative stress and DNA damage
We subjected yeast to two stresses, oxidative stress, which under current settings induces a fast and transient response in mRNA abundance, and DNA damage, which triggers a slow enduring response. Using microarrays, we performed a transcriptional arrest experiment to measure genome-wide mRNA decay p...
ORGANISM(S): Saccharomyces cerevisiae 
2008-10-26 | E-GEOD-12221 | biostudies-arrayexpress
ProteomicsSequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons
Alpha-synuclein (αSyn) protein levels correlate with the risk and severity of Parkinson's disease and related neurodegenerative diseases. Lowering αSyn is being actively investigated as a therapeutic modality. Here we systematically map the regulatory network that controls endogenous αSyn using sequ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD048283 | Pride
Crispr Alpha-synuclein Natb inhibition Parkinson's disease Human neurons 
TranscriptomicsTranscription profiling of S. cerevisiae reveals transient transcriptional responses to stress are generated by opposing effects of mRNA production and degradation
This SuperSeries is composed of the following subset Series:; GSE12220: Changes in Saccharomyces cerevisiae mRNA abundance following oxidative stress and DNA damage stress; GSE12221: Decay profiles of Saccharomyces cerevisiae mRNAs following oxidative stress and DNA damage Experiment Overall Design:...
ORGANISM(S): Saccharomyces cerevisiae 
2008-10-26 | E-GEOD-12222 | biostudies-arrayexpress
TranscriptomicsSignaling to Transcription Networks in the Neuronal Retrograde Injury Response
Retrograde signaling from axon to soma activates intrinsic regeneration mechanisms in lesioned peripheral sensory neurons; however, the links between axonal injury signaling and the cell body response are not well understood. Here, we used phosphoproteomics and microarrays to implicate ~900 phosphop...
ORGANISM(S): Rattus norvegicus 
2010-12-29 | E-GEOD-26350 | biostudies-arrayexpress
TranscriptomicsMeasurements of mRNA abundance and decay for two strains 211 (wt) and 212 (mutant)
For each strain two time courses for mRNA abundance: Oxidative and MMS and two time courses for decay: reference decay and following oxidative stress We used Affymetrix microarrays to quantify changes in mRNA abundance following oxidative stress and DNA damage stress and also decay following transcr...
ORGANISM(S): Saccharomyces cerevisiae 
2011-07-29 | E-GEOD-26829 | biostudies-arrayexpress
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