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TranscriptomicsGene expression study identifies important protective pathways utilized by appendicitis and appendectomy for ameliorating colitis
BACKGROUND: Appendicitis followed by appendectomy (AA) at a young age protects against later inflammatory bowel disease (IBD). Using a novel murine appendicitis model we earlier demonstrated that AA proffered significant protection against subsequent experimental colitis. AIM: To delineate genes and...
ORGANISM(S): Mus musculus 
2010-09-01 | E-GEOD-23914 | biostudies-arrayexpress
TranscriptomicsReverse myocardial remodeling by aortic bending debanding in mice
The objective of this study was to identify alterations in gene expression during reverse myocardial remodeling in a mouse model of reversible pressure overload. Mice were subjected to 4 weeks of aortic banding (AB) or sham procedure (sAB), banding and subsequent debanding (DB3), or sham procedure a...
ORGANISM(S): Mus musculus 
2010-09-29 | E-GEOD-24454 | biostudies-arrayexpress
UnknownRecording brain responses to TMS of primary motor cortex by EEG - utility of an optimized sham procedure.
Not available
S-EPMC8752966 | biostudies-literature
TranscriptomicsMicroRNA transciptional profiling in murine abdominal aortic aneurysm (AAA), porcine pancreatic elastase (PPE) model - Day 7
We sought to identify differentially regulated microRNAs in infrarenal mouse aortic tissue after AAA-induction with PPE, compared with sham-operated mice. This treatment leads to rapid development of infrarenal aortic aneurysms with significant diameter differences observed by Day 7. We found 41 miR...
ORGANISM(S): Mus musculus 
2014-08-31 | E-GEOD-51226 | biostudies-arrayexpress
TranscriptomicsThrombopoietin (TPO) protects against heart damage induced infarction in rat model
In order to examine the mechanism of TPO on cardiac protection against myocardial infarction damage (MI), we have employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential to delineate the TPO cardioprotective mechanism against infarction. MI ...
ORGANISM(S): Rattus norvegicus 
2012-12-01 | E-GEOD-22489 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of ischemia-reperfused Rattus norvegicus heart tissue samples
Rats underwent surgery for LAD ligation for 30 min followed by reperfusion. Heart ventricles were collected 2d or 7d after reperfusion. Experiment Overall Design: rats were divided in following groups that underwent LAD occlusion or not (SHAM): Experiment Overall Design: 1. 7d-IR (n=3) Experiment O...
ORGANISM(S): Rattus norvegicus 
2007-11-06 | E-GEOD-4105 | biostudies-arrayexpress
TranscriptomicsMicroarray Analysis Gene Expression Profiles in Laryngeal Muscle After Recurrent Laryngeal Nerve Injury
The pathophysiology of recurrent laryngeal nerve (RLN) transection injury is rare in that it is characteristically followed by a high degree of spontaneous reinnervation, with reinnervation of the laryngeal adductor complex (AC) preceding that of the abducting posterior cricoarytenoid (PCA) muscle. ...
ORGANISM(S): Rattus norvegicus 
2016-07-01 | E-GEOD-72361 | biostudies-arrayexpress
TranscriptomicsLeft ventricular myocardial transcriptomic profiling for target discovery in a rat model of pressure overload-induced heart failure
Left ventricular myocardial transcriptomic profiling was performed in rats subjected to transverse aortic constriction (TAC)-induced heart failure and sham-operated controls to investigate gene expression changes associated with pressure overload-induced cardiac remodeling. The dataset was used in s...
ORGANISM(S): Rattus norvegicus 
2026-06-11 | E-MTAB-17114 | biostudies-arrayexpress
TranscriptomicsGene expression in respiratory epithelial cells treated to induce StIR
Pneumonia is a serious problem worldwide. We recently demonstrated that innate defense mechanisms of the lung are highly inducible against pneumococcal pneumonia. To determine the breadth of protection conferred by stimulation of lung mucosal innate immunity, and to identify cells and signaling pa...
ORGANISM(S): Mus musculus 
2010-06-24 | E-GEOD-13685 | biostudies-arrayexpress
TranscriptomicsTranscriptome of the bone metastasis associated stroma
The reciprocal interaction between cancer cells and the tissue-specific stroma is critical for primary and metastatic tumor growth progression. Prostate cancer cells colonize preferentially bone (osteotropism), where they alter the physiological balance between osteoblast-mediated bone formation and...
ORGANISM(S): Mus musculus 
2014-12-09 | E-GEOD-22813 | biostudies-arrayexpress
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