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ProteomicsRadical footprinting in mammalian whole blood
Hydroxyl Radical Protein Footprinting (HRPF) is a powerful tool to probe protein higher-order structure, as well as protein-protein and protein-carbohydrate interactions. It is mostly performed in vitro, but recent advances have extended its use to live cells, nematodes, and 3D cultures. However, ap...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-13 | PXD064571 | Pride
Hrpf Targeted analysis Mouse blood Diabetes mellitus 
ProteomicsInline Liquid Chromatography-Fast Photochemical Oxidation of Proteins Allows for Targeted Structural Analysis of Conformationally Heterogeneous Mixtures
The size exclusion was used to separate the mixture of holomyoglobin and apomyoglobin as well as native and aggregated adalimumab, just before laser irrdiation for FPOP. The footprint of the individual proteins were determined.
ORGANISM(S): Bos taurus (Bovine) 
2022-02-16 | PXD023402 | Pride
Hrpf Biosimilar Inline fpop Higher order structure 
ProteomicsDerivatized heparin hexaccharides LC-MS/MS
We have developed a novel chemical derivatization method coupled tandem mass spectrometry to resolve the structural sequences of sulfated glycosaminoglycans. In order to evaluate and demonstrate our method capable for native sulfated oligosaccharides, a complex heparin hexasaccharide was used.
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2020-09-21 | PXD021263 | Pride
Glycan Heparin hexaccharides Lc-ms/ms 
ProteomicsStructural Analysis of Phosphorylation Proteoforms in a Dynamic Heterogeneous System Using Flash Oxidation Coupled In-Line with Ion Exchange Chromatography
Protein post-translational modifications (PTMs) are key modulators of protein structure and function that often change in a dynamic fashion in response to cellular stimuli. Dynamic post-translational modifications are very challenging to structurally characterize using modern techniques, including c...
ORGANISM(S): Gallus gallus (Chicken) 
2023-01-16 | PXD037050 | Pride
Flash oxidation Ovalbumin Phosphoproteoforms Lc-fox 
ProteomicsMapping the binding site of VAR2CSA to chondroitin sulfate A
The FPOP was performed in order to map the binding site of chondroitin sulfate A to VAr2CSA from Plasmodium.
ORGANISM(S): Plasmodium falciparum FcB1/Columbia 
2021-04-09 | PXD024154 | Pride
Chondoitin sulfate a Hrpf Var2csa Fpop 
UnknownFive-year survival outcomes for patients with advanced melanoma treated with pembrolizumab in KEYNOTE-001.
Not available
S-EPMC6503622 | biostudies-literature
UnknownGlobal anaesthesia practice using inguinal hernia surgery as a tracer condition: a secondary analysis of an international prospective cohort study.
Not available
S-EPMC12519944 | biostudies-literature
UnknownSARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.
Not available
S-EPMC7995808 | biostudies-literature
UnknownTiming of surgery following SARS-CoV-2 infection: an international prospective cohort study.
Not available
S-EPMC8206995 | biostudies-literature
UnknownSARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study.
Not available
S-EPMC8652887 | biostudies-literature
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