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ProteomicsStaphylococcus aureus USA300 LAC and XdrA mutant strain, secretome, Exponential phase, Stationary phase, LC-MS/MS, Orbitrap
The success of Staphylococcus aureus as a pathogen results from the production of a wealth of virulence determinants that aid in immune evasion, host cell invasion and dissemination of infection. Given the niche specific roles of these factors in infection, their production is controlled by a comple...
ORGANISM(S): Staphylococcus aureus 
2022-04-08 | PXD026577 | Pride
Xdra Bacteria Mid exponential growth phase Orbitrap Staphylococcus aureus Pathogenesis Lc-ms/ms 
ProteomicsInsight into the Human Pathodegradome of the V8 protease from Staphylococcus aureus
The major human pathogen Staphylococcus aureus possesses ten extracellular proteases that are central to the virulence process. While some host targets of these and other bacterial proteases are known, a major bottleneck to the study of their function is the low-throughout nature of substrate identi...
ORGANISM(S): Homo sapiens (Human) Staphylococcus aureus 
2021-03-29 | PXD014797 | Pride
Host-pathogen interactions Immunology Microbiology N-terminomics Staphylococcus aureus Degradomics 
TranscriptomicsTubal ectopic pregnancy as a model to identify endometrial genes and signaling pathways important in decidualization and regulated by local trophoblast
Gestation-matched endometrium was collected from women with ectopic pregnancy (EP) (n=11) and intrauterine pregnancies (IUP) (n=13). RNA was extracted from the tissue. In addition, tissues were prepared for histological analysis for degree of decidualization. We compared a) the samples from EP that ...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-MTAB-680 | biostudies-arrayexpress
TranscriptomicsGenes enabling phenotypic plasticity evolve canalized gene expression by their limited associations with transcriptional regulators
Global climate change increasingly polarizes environments, presenting unprecedented challenges to many organisms (Smol, 2012). Polarization occurs not only in the spatial dimension, producing greater desert drought and tropical rainfall, for example, but also in the temporal dimension by making a lo...
ORGANISM(S): Fundulus heteroclitus 
2014-10-02 | E-GEOD-47035 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse HSC at various time points after treatment with 5-Fluorouracil
HSC (Sca+ SP) were isolated from 8-12 week C57B6 mice at various time points after treatment with 5-Fluorouracil. RNA was isolated from 50,000-100,000 FACS sorted cells and subjected to two rounds of T7 based linear amplification using Ambion's Message Amp kit. Two replicates from each time point w...
ORGANISM(S): Mus musculus 
2007-11-15 | E-GEOD-1559 | biostudies-arrayexpress
UnknownVitamin D did not reduce multiple sclerosis disease activity after a clinically isolated syndrome.
Not available
S-EPMC10994527 | biostudies-literature
UnknownMicrofluidics combined with electron microscopy for rapid and high-throughput mapping of antibody-viral glycoprotein complexes.
Not available
S-EPMC12404239 | biostudies-literature
TranscriptomicsAMPK and calcineurin induced longevity is mediated by CRTC-1 and CREB
AMPK (AAK-2) and calcineurin (TAX-6) mediate longevity exclusively through post-translational modification of CRTC-1, the sole C. elegans CRTC (CREB regulated transcriptional coactivator). We performed microarrays to examine the transcriptional responses elicited by the pro-longevity: activation of ...
ORGANISM(S): Caenorhabditis elegans 
2010-11-20 | E-GEOD-25513 | biostudies-arrayexpress
TranscriptomicsComparative Genome-Wide Transcriptional Analysis of Bilateral Internal Mammary Arteries
In Coronary Artery Bypass Grafting (CABG), the combined use of Left or Right Internal Mammary Artery (LIMA or RIMA) -collectively known as Bilateral IMAs (BIMAs)- provides a survival advantage over the LIMA alone. Several studies analyzed the gene expression in LIMAs and other conduits, however they...
ORGANISM(S): Homo sapiens 
2012-10-31 | E-GEOD-41036 | biostudies-arrayexpress
TranscriptomicsGBM-Space: Joint Transcriptome and Chromatin Accessibility Profiling of Glioblastoma (10x Genomics - Multiome)
Cancer cells display highly heterogeneous and plastic states in glioblastoma, an incurable brain tumour. However, how these malignant states arise and whether they follow defined cellular trajectories across tumours is poorly understood. Here, we generated a deep single cell and spatial multi-omic a...
ORGANISM(S): Homo sapiens 
2026-09-12 | E-MTAB-17183 | biostudies-arrayexpress
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