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TranscriptomicsTranscriptional landscape of transkingdom communication between Candida albicans and Streptococcus gordonii
Recent studies have shown that the transcriptional landscape of the pleiomorphic fungus Candida albicans is highly dependent upon growth conditions. Here using a dual RNA-seq approach we identified 299 C. albicans and 72 Streptococcus gordonii genes that were either up- or down-regulated specificall...
ORGANISM(S): Candida albicans 
2015-06-22 | E-GEOD-68477 | biostudies-arrayexpress
GenomicsGenome-wide analysis reveals that budding yeast Rif1 binds to replication origins and at blocked replication forks to protect nascent DNA
This experiment details ChIP sequencing to decipher the binding sites of the Rif1 protein in budding yeast. Rif1 binds most strongly to telomeres where its binding is mediated by Rap1. To reduce telomere binding and help reveal Rap1-independent binding sites, a truncation mutant of Rif1 lacking the ...
ORGANISM(S): Saccharomyces cerevisiae 
2018-12-31 | E-MTAB-6736 | biostudies-arrayexpress
ProteomicsBeta-glucan is a major growth substrate for human gut bacteria related to Coprococcus eutactus
A clone encoding carboxymethylcellulase activity was isolated during functional screening of a human gut metagenomic library using Lactococcus lactis MG1363 as heterologous host. The insert sequence revealed a glycoside hydrolase family 9 (GH9) catalytic domain with sequence similarity to a gene fro...
ORGANISM(S): Coprococcus sp. ART55/1 
2020-03-10 | PXD014174 | Pride
Coprococcus eutactus  beta-glucan 
GenomicsIdentification of Elg1 interaction partners and effects on post-replication chromatin re-formation
Elg1, the major subunit of a Replication Factor C-like complex, is critical to ensure genomic stability during DNA replication, and is implicated in controlling chromatin structure. We investigated the consequences of Elg1 loss for the dynamics of chromatin re-formation following DNA replication. Me...
ORGANISM(S): Saccharomyces cerevisiae 
2018-10-31 | E-MTAB-6985 | biostudies-arrayexpress
GenomicsSWI/SNF and the histone chaperone Rtt106 drive expression of the Pleiotropic Drug Resistance network genes
Genome-wide binding of the histone chaperone Rtt106 was analysed by ChIP-seq. Rtt106 binding was analysed in WT and the mutant backgrounds lacking transcription factors Pdr1 and Pdr3, the HIR histone chaperone subunit Hir1, or the boundary protein Yta7. Two biological replicates had been submitted. ...
ORGANISM(S): Saccharomyces cerevisiae 
2022-02-21 | E-MTAB-9787 | biostudies-arrayexpress
TranscriptomicsContribution of the Hog1 SAPK to nitrosative stress response in Candida albicans.
RNA sequencing was performed on Candida albicans wild type cells (JC50) grown to exponential phase on YPD , YPD plus Nitrosative Stress 2.5mM DPTA NONOate, and compared to exponential Candida albicans hog1 deletion mutant cells grown on on YPD , YPD plus Nitrosative Stress 2.5mM DPTA NONOate. Three...
ORGANISM(S): Candida albicans 
2018-03-02 | E-MTAB-5990 | biostudies-arrayexpress
TranscriptomicsDiet induced obesity is independent of metabolic endotoxemia, Tlr4 signalling and hypothalamic inflammation
A number of studies have proposed that excess food intake, particularly of high fat diets arise due dysregulation of homeostatic mechanisms regulating neuroendocrine control of appetite and energy balance. Current dogma suggests high fat diets invoke hypothalamic inflammation which reduces hypothala...
ORGANISM(S): Mus musculus 
2018-10-23 | E-MTAB-6929 | biostudies-arrayexpress
TranscriptomicsBeta-glucan is a major growth substrate for human gut bacteria related to Coprococcus eutactus
The gut bacterium Coprococcus sp. ART55/1 has been found to encode two genes containing glycoside hydrolase family 9 (GH9) catalytic domains. These genes are hypothesised to impact upon the ability of this bacteria to utilise different carbon sources. To further investigate the role of these genes, ...
ORGANISM(S): Coprococcus sp. ART55/1 
2020-03-09 | E-MTAB-8048 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing reveals allelic expression imbalance in the diploid pathogen Candida albicans
The diploid fungal pathogen Candida albicans is a highly heterozygous organism, with numerous non-synonymous substitutions often seen within two alleles. RNA-sequencing of the wild-type strain SC5314 has revealed 233 genes with significant levels of allelic expression imbalance. Overall percentage p...
ORGANISM(S): Candida albicans 
2014-06-30 | E-GEOD-35233 | biostudies-arrayexpress
UnknownPooled Analysis of CNS Response to Alectinib in Two Studies of Pretreated Patients With ALK-Positive Non-Small-Cell Lung Cancer.
Not available
S-EPMC7845943 | biostudies-literature
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