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TranscriptomicsRegulation of the Mycobacterium tuberculosishypoxic response gene encoding alpha-crystallin
Unlike many pathogens that are overtly toxic to their hosts, the primary virulence determinant of Mycobacterium tuberculosis appears to be its ability to persist for years or decades within humans in a clinically latent state. Since early in the 20th century latency has been linked to hypoxic condit...
ORGANISM(S): Mycobacterium tuberculosis 
2010-06-05 | E-GEOD-8639 | biostudies-arrayexpress
TranscriptomicsExtensive promoter-centered chromatin interactions provide a topological basis for transcription regulation
Higher-order chromosomal organization for transcription regulation is poorly understood in eukaryotes. Using genome-wide Chromatin Interaction Analysis with Paired-End-Tag sequencing (ChIA-PET), we mapped long-range chromatin interactions associated with RNA polymerase II in human cells and uncovere...
ORGANISM(S): Homo sapiens 
2012-01-20 | E-GEOD-33664 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Mycobacterium tuberculosis grown at reduced oxygen tension to identify regulators of the hypoxic response
Unlike many pathogens that are overtly toxic to their hosts, the primary virulence determinant of Mycobacterium tuberculosis appears to be its ability to persist for years or decades within humans in a clinically latent state. Since early in the 20th century latency has been linked to hypoxic condit...
ORGANISM(S): Mycobacterium tuberculosis 
2007-09-12 | E-TABM-312 | biostudies-arrayexpress
TranscriptomicsA master cistromic circuit governing hepatic fibrogenesis [expression array]
Liver fibrosis is a reversible wound-healing response to liver injury and hepatic stellate cells (HSCs) are central cellular players that mediate hepatic fibrogenesis. However, the molecular mechanisms that govern this process remain unclear. Expression profiling was used to explore the potential im...
ORGANISM(S): Rattus norvegicus 
2013-04-29 | E-GEOD-41579 | biostudies-arrayexpress
TranscriptomicsDefined hypoxic model timecourse of H37Rv and H37Rv:deltadosR
Background: A significant body of evidence accumulated over the last century suggests a link between hypoxic microenvironments within the infected host and the latent phase of tuberculosis. Studies to test this correlation have identified the M. tuberculosis initial hypoxic response, controlled by ...
ORGANISM(S): Mycobacterium tuberculosis 
2008-02-20 | E-GEOD-9331 | biostudies-arrayexpress
TranscriptomicsMycobacterium tuberculosis H37Rv transcriptional response to antibacterial agents
Bacteria commonly adapt to stresses by altering gene expression. To understand the response of M. tuberculosis (MTB) to various antibacterial agents, we performed transcriptomics on MTB bacilli exposed to several test compounds as well as known drugs (capreomycin, cycloserine, ethionamide, isoniazi...
ORGANISM(S): Mycobacterium tuberculosis 
2015-11-11 | E-GEOD-71200 | biostudies-arrayexpress
UnknownDevelopment and Preliminary Validation of an Instrument to Measure Symptoms and Impacts in Patients with Proliferative Diabetic Retinopathy.
Not available
S-EPMC9969934 | biostudies-literature
UnknownA Multimodal System for Lipid A Structural Analysis from a Single Colony.
Not available
S-EPMC11359392 | biostudies-literature
TranscriptomicsDistinct classes of genes behave as either drivers or dependents of replication timing switches (Replication-Timing).
Duplication of the genome in mammalian cells occurs in a defined temporal order referred as its replication-timing program (RT). RT is regulated in units of 400-800 Kb referred as replication domains (RDs) and changes dynamically during development. Changes in RT are generally coordinated with trans...
ORGANISM(S): Homo sapiens 
2015-05-28 | E-GEOD-63428 | biostudies-arrayexpress
UnknownComputational Design of Lysine Targeting Covalent Binders Using Rosetta.
Not available
S-EPMC12152945 | biostudies-literature
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