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TranscriptomicsTranscription profiling of human MCF7/BUS cell culture exposed to xenoestrogens
MCF7 cells were exposed to xenoestrogens (vehicle = 0.1% ethanol, 30 pM 17beta-estradiol, 3 micromolar genistein, 10 micromolar genistein, 1 micomolar daidzein, 10 nM bisphenol A, 10 nM para-nonylphenol, 3 nM PPT) for 48 hours. Experiment Overall Design: MCF7/BUS cells were exposed to xenoestrogens ...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-5200 | biostudies-arrayexpress
TranscriptomicsTranscriptomes of mouse PGCLCs isolated from 6-day culture embryoid bodies were compared with transcriptomes of their precur cells (ESCs, iPSCs, and EpiLCs) and E12.5 in vivo mouse PGCs
Transcriptomes of mouse E12.5 primordial germ cells (PGCs), primordial germ cell-like cells (PGCLCs) isolated from 6-day culture embryoid bodies, and the precursor pluripotent stem cells [embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs)] and epiblast-like cells (EpiLCs) Total ...
ORGANISM(S): Mus musculus 
2016-08-22 | E-GEOD-80983 | biostudies-arrayexpress
TranscriptomicsAsymmetric cancer cell division regulated by AKT, Reactive Oxygen Species (ROS) high versus ROS low mRNA
Human tumors often contain slowly proliferating cancer cells that resist treatment but we do not know precisely how these cells arise. We show that rapidly proliferating cancer cells can divide asymmetrically to produce slowly proliferating “G0-like” progeny that are enriched following chemotherapy ...
ORGANISM(S): Homo sapiens 
2011-07-14 | E-GEOD-30465 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human MCF-7 cells treated with Fulvestrant (ICI 182,780) and vehicle reveals origins and phenotypic variations of antiestrogen resistance in breast cancer
Expression profiles of MCF-7 cells treated with Fulvestrant (ICI 182,780) and vehicle Experiment Overall Design: MCF7 cells were grown in DMEM supplemented with 5% FCS (Hyclone, "Defined" grade). Growth medium was changed immediately before addition of 100 nM of ICI 182,780 or vehicle alone (0.1% et...
ORGANISM(S): Homo sapiens 
2009-09-15 | E-GEOD-14986 | biostudies-arrayexpress
TranscriptomicsAll-iPS cell mice generated from terminally differentiated B cells
The generation of induced pluripotent stem cells (iPSCs) often results in aberrant silencing of the imprinted Dlk1-Dio3 gene cluster, which compromises their ability to generate entirely iPSC-derived mice (“all-iPSC mice”). Here, we show that reprogramming in the presence of ascorbic acid attenu...
ORGANISM(S): Mus musculus 
2012-02-01 | E-GEOD-34761 | biostudies-arrayexpress
TranscriptomicsExpression data from zinc-finger-transcription-factor-induced Fulvestrant-Resistant MCF7 Cell Lines
Multiple gene expression studies have demonstrated that breast cancer biological diversity is associated with distinct transcriptional programs. Transcription factors, because of their unique ability to coordinate the expression of multiple genes, are speculated to play a role in generating phenotyp...
ORGANISM(S): Homo sapiens 
2011-07-17 | E-GEOD-27444 | biostudies-arrayexpress
TranscriptomicsTranscriptomal effects of four-day exposure to estradiol on mouse primary culture urogenital sinus mesenchymal cells of fetal mouse prostate
Developmental exposure of mouse fetuses to estrogens results in dose-dependent permanent effects on prostate morphology and function. Fetal prostatic mesenchyme cells express estrogen receptor alpha (ERα) and androgen receptors and convert stimuli from estrogens and androgens into signaling to regul...
ORGANISM(S): Mus musculus 
2012-03-21 | E-GEOD-36630 | biostudies-arrayexpress
TranscriptomicsEarly passage mouse induced pluripotent stem (iPS) cells derivated from various somatic cell origins
Induced pluripotent stem (iPS) cells have been derived from various somatic cell populations through ectopic expression of defined factors. It remains unclear whether iPS cells generated from different cell types are molecularly and functionally similar. Here, we show that iPS cells obtained from fi...
ORGANISM(S): Mus musculus 
2010-07-19 | E-GEOD-22908 | biostudies-arrayexpress
TranscriptomicsGene expression in adipose tissue of intrauterine growth restricted (IUGR) and Macrosomic animals that developed in a crowded uterine horn
Animals that are growth restricted in utero may show rapid postnatal growth that ultimately results in adult obesity. Macrosomic animals at birth typically remain large and are also obese as adults. Our goal was to examine the differences between animals that reach obesity in different ways. We a...
ORGANISM(S): Mus musculus 
2012-04-24 | E-GEOD-33761 | biostudies-arrayexpress
Genomicsena-DATASET-MGH-CC-08-07-2015-20:42:52:693-393 - samples
Description not provided
EGAD00001001436 | EGA
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