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TranscriptomicsTranscriptional regulation of the sialic acid utilization gene cluster of Bifidobacterium breve UCC2003 by a GntR-type transcriptional repressor.
Members of the genus Bifidobacterium are typically found in the gastrointestinal tract (GIT) of humans and other mammals. Bifidobacterium breve strains are numerically prevalent among the gut microbiota of healthy, breast-fed infants. The metabolism of sialic acid, a ubiquitous monosaccharide in the...
ORGANISM(S): Bifidobacterium breve UCC2003 
2015-03-05 | E-GEOD-62885 | biostudies-arrayexpress
ProteomicsA Linkage- Specific Sialic Acid Labeling Strategy Reveals Different Site-Specific Glycosylation Patterns in SARS-CoV-2 Spike Protein Produced in CHO and HEK Cell Substrates
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus utilizes an extensively glycosylated spike protein that protrudes from the viral envelope to bind to angiotensin-converting enzyme-related carboxypeptidase (ACE2) as its primary receptor to mediate host-cell entry. Currently, the...
ORGANISM(S): Homo sapiens (Human) Cricetulus barabensis 
2022-02-17 | PXD027536 | Pride
Lc-msms Glycopeptide Recombinant sars-2 spike Sialic acids labeling 
TranscriptomicsMetabolism of sialic acid by Bifidobacterium breve UCC2003
Bifidobacteria constitute a specific group of commensal bacteria which inhabit the gastrointestinal tract of humans and other mammals. Bifidobacterium breve UCC2003 has previously been shown to utilise several plant-derived carbohydrates that include cellodextrins, starch and galactan. In the curren...
ORGANISM(S): Bifidobacterium breve UCC2003 
2014-05-29 | E-GEOD-56291 | biostudies-arrayexpress
ProteomicsEfficient TurboID-based proximate labeling method for identifying terminal sialic acid glycosylation in living cells
TurboID, a mutant biotin ligase, based proximity labeling method is a new efficient technique for recognizing protein-protein interactions and has been successfully applied to living cells. Sialic acids are typically the terminal monosaccharides attached to many glycoproteins and play many important...
ORGANISM(S): Homo Sapiens 
2021-11-04 | PXD029556 |
TranscriptomicsTranscription profiling of mouse tumors arising in wild-type or St6gal1 null littermates
Sialic acids on vertebrate cell surfaces mediate many biological roles. Altered expression of certain sialic acid types or their linkages can have prognostic significance in human cancer. A classic but unexplained example is enhanced α2-6-sialylation on N-glycans, resulting from over-expression of ...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9447 | biostudies-arrayexpress
GenomicsHuman NXPE1 mediates variation in sialic acid O-acetylation in Colon Tissue
Sialylation, and its modifications, have important consequences for development, differentiation and immune system regulation in nearly all human tissues. An accounting of all the genes responsible for modifying sialic acids is incomplete, with only one pathway for O-acetylation being well-defined i...
EGAS00001007704 | EGA
ProteomicsSialic Acid Linkage-Specific Alkylamidation-Based Method for Comprehensive N- and O-Glycoproteomic Profiling of Human Plasma
Sialic acids are attached to glycoproteins via alpha2,3- or alpha2,6-linkages and play important roles in disease pathogenesis. Sialyl linkage-specific derivatization of intact N- and/or O-glycopeptides remains challenging because of the diverse reactive functional groups within peptides. In this re...
ORGANISM(S): Homo Sapiens (human) 
2026-06-10 | PXD080569 | JPOST Repository
UnknownModification of Sialic Acids on Solid Phase: Accurate Characterization of Protein Sialylation.
Not available
S-EPMC5583724 | biostudies-literature
UnknownMetabolic labeling of sialic acids in living animals with alkynyl sugars.
Not available
S-EPMC2868584 | biostudies-literature
UnknownStructure-Activity Relationship of Metabolic Sialic Acid Inhibitors and Labeling Reagents.
Not available
S-EPMC8938927 | biostudies-literature
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