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MetabolomicsA cytochrome P450 CYP87A4 imparts sterol side-chain cleavage in digoxin biosynthesis
Digoxin extracted from the foxglove plant is a widely prescribed natural product for treating heart failure. It is listed as an essential medicine by the World Health Organization. However, how the foxglove plant synthesizes digoxin is mostly unknown, especially the cytochrome P450 sterol side chain...
2025-07-03 | MTBLS7993 | MetaboLights
ProteomicsFormaldehyde derivatization, a Side Reaction During Filter-Aided Sample Preparation
The filter-aided sample preparation (FASP) method has been commonly used for proteomic sample preparation due to its high efficiency and convenience. Herein, we report an overlooked side reaction during FASP method, resulting in a mass increment of 12 Da. We confirmed that the side reaction is cause...
ORGANISM(S): Caenorhabditis elegans 
2020-08-20 | PXD018737 | Pride
Filter-aided sample preparation Side reaction Formaldehyde derivatization 
TranscriptomicsDiscovery of Shear- and Side-specific mRNAs and miRNAs in Human Aortic Valvular Endothelial Cells
Identify shear and side-specific miRNAs in Human Aortic Valvular Endothelial Cells using the following conditions: 1) fHAVEC exposed to OS (FO), 2) vHAVEC exposed to OS (VO), 3) fHAVEC exposed to LS (FL), and 4) vHAVEC exposed to LS (VL). 24 samples; n=6 for the following 4 groups: FO, VO, FL, and V...
ORGANISM(S): Homo sapiens 
2011-11-29 | E-GEOD-26953 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human conjunctival epithelial side population cells
Side population (SP) cells isolated from limbal and conjunctival epithelia derive from cells that are slow cycling in vivo, a known feature of tissue stem cells. The purpose of this study was to define the molecular signature of the conjunctival side population cells by global differential gene expr...
ORGANISM(S): Homo sapiens 
2009-11-11 | E-GEOD-12631 | biostudies-arrayexpress
ModelsThiaville2016 - Wild type folate pathway model with proposed PanB reaction
Thiaville2016 - Wild type folate pathway model with proposed PanB reaction This is a wild type E. coli model, and is one amongst the three models described in the paper. The other two models are MODEL1602280002 (wild type with PanB over expression) and MODEL1602280003 (wild type with PanB over expre...
2024-09-02 | BIOMD0000000639 | BioModels
ProteomicsDeciphering Diazirine Reaction Mechanism: through Irradiation Modulation for Residue-Specific Distance Restraints in Protein Photo-Crosslinking
The diazirine photoreactive group has been widely used for photo-labeling and photo-cross-linking (PXL) of proteins. Yet, due to the mechanistic complexity of diazirine photo-reaction, site-specific and quantitative analysis of protein PXL data remains challenging. Herein, we have built an in-line p...
ORGANISM(S): Bos taurus (Bovine) 
2024-06-22 | PXD048452 | Pride
Photo cross-linking Multiple reaction monitoring Optical power density Distance restraints Alkyl diazirine 
TranscriptomicsSide population cells in human primary melanoma
Melanoma remains the most lethal skin cancer, mainly because of high resistance to therapy. Side population (SP) cells are found in many types of cancer and are usually enriched in therapy-resistant as well as tumorigenic cells. Here, we identified a Hoechst dye-effluxing SP in a large series of hum...
ORGANISM(S): Homo sapiens 
2014-05-27 | E-GEOD-48838 | biostudies-arrayexpress
TranscriptomicsHuman pancreatic adenocarcinoma contains a side population resistant to gemcitabine
BACKGROUND: Therapy resistance remains one of the major challenges to improve the prognosis of patients with pancreatic cancer. Chemoresistant cells, which potentially also display cancer stem cell (CSC) characteristics, can be isolated using the side population (SP) technique. Our aim was to search...
ORGANISM(S): Homo sapiens 
2016-01-04 | E-GEOD-36563 | biostudies-arrayexpress
UnknownThe hydrogenation side-reaction in copper-mediated radiofluorination.
Not available
S-EPMC12417351 | biostudies-literature
ProteomicsAn Undesirable Side Effect of EDC-catalyzed Carboxyl Labeling Approach
Carbodiimide catalyzed carboxyl and amine conjugation (amidation) has been widely used to protect carboxyl groups. N-(3-dimethylaminopropyl)-N’-ethylcarbodiimide (EDC) is the most commonly used carbodiimide reagent in protein chemis-try due to its high efficiency and high solubility in aqueous media...
ORGANISM(S): Homo sapiens (Human) 
2020-12-10 | PXD020042 | Pride
Tyrosine Carboxyl protection C-tails Edc 
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