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UnknownNrf2 mitigates prolonged PM2.5 exposure-triggered liver inflammation by positively regulating SIKE activity: Protection by Juglanin.
Not available
S-EPMC7387847 | biostudies-literature
UnknownMechanism of endogenous regulation of the type I interferon response by suppressor of IκB kinase epsilon (SIKE), a novel substrate of TANK-binding kinase 1 (TBK1).
Not available
S-EPMC3690000 | biostudies-literature
ProteomicsSuppressor of IKKepsilon forms direct interactions with cytoskeletal proteins, tubulin and alpha-actinin, linking innate immunity to the cytoskeleton
Suppressor of IKKepsilon (SIKE) is associated with the innate immune system’s type I interferon response through TANK binding kinase 1 (TBK1). Characterized as an endogenous inhibitor of TBK1 when overexpressed in viral infection and pathological cardiac hypertrophic models, mechanistic study revea...
ORGANISM(S): Homo sapiens (Human) 
2018-05-29 | PXD007262 | Pride
Innate immunity Cytoskeleton Sike Tubulin Alpha-actinin 
Genomics
Effect of SIKE gene deficiency on PO-induced NASH of hepatocytes
PRJNA1023382 | ENA
Genomics
Effect of TAK1 gene silencing in hepatocytes on SIKE deletion-led activation of HFHC-induced NASH in mice
PRJNA1024654 | ENA
Genomics
Effect of SIKE gene deficiency in hepatocytes on HFHC-induced NASH in mice
PRJNA1023383 | ENA
Genomics
Effect of SIKE gene overexpression in hepatocytes on HFHC diet-induced NASH in mice
PRJNA1024948 | ENA
Genomics
Effect of indobufen treatment on HFHC diet-induced MAPK activation and NASH in Sike KO mice
PRJNA1024667 | ENA
UnknownSuppressor of IKKepsilon forms direct interactions with cytoskeletal proteins, tubulin and α-actinin, linking innate immunity to the cytoskeleton.
Not available
S-EPMC6026704 | biostudies-literature
UnknownSuppressor of IKKɛ is an essential negative regulator of pathological cardiac hypertrophy.
Not available
S-EPMC4895691 | biostudies-literature
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