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ProteomicsQuantitative proteomics identifies Ola1p as a positive regulator of heat shock response in Saccharomyces cerevisiae
Ola1 is implicated in various stress response pathways, as well as in cancer and tumor progression. However, Ola1p functions are divergent between species and still remain poorly understood. Here, we studied the role of Ola1p in the heat shock response in Saccharomyces cerevisiae. We show that delet...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-02-17 | PXD025615 | Pride
Proteomics Heat shock recovery Saccharomyces cerevisiae Native silac Pulsed silac 
ProteomicsDeubiquitinase activity is required for the degradation of misfolded cytosolic proteins upon heat-stress
Elimination of misfolded proteins is crucial for proteostasis and to prevent proteinopathies. Nedd4/Rsp5 emerged as a major E3 ligase involved in multiple quality control pathways that target misfolded plasma membrane proteins, aggregated polypeptides, and cytosolic heat-induced misfolded proteins f...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-03-01 | PXD004747 | Pride
Deubiquitinase Cytosolic protein quality control Heat stress 
ProteomicsQuantitative proteomics identifies Ola1p as a positive regulator of heat shock response in Saccharomyces cerevisiae
Ola1 is implicated in various stress response pathways, as well as in cancer and tumor progression. However, Ola1p functions are divergent between species and still remain poorly understood. Here, we studied the role of Ola1p in the heat shock response in Saccharomyces cerevisiae. We show that delet...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-02-17 | PXD025673 | Pride
Proteomics Heat shock recovery Saccharomyces cerevisiae Native silac Pulsed silac 
ProteomicsQuantitative proteomics identifies Ola1p as a positive regulator of heat shock response in Saccharomyces cerevisiae
Ola1 is implicated in various stress response pathways, as well as in cancer and tumor progression. However, Ola1p functions are divergent between species and still remain poorly understood. Here, we studied the role of Ola1p in the heat shock response in Saccharomyces cerevisiae. We show that delet...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-02-17 | PXD025614 | Pride
Proteomics Heat shock recovery Saccharomyces cerevisiae Native silac Pulsed silac 
ProteomicsQuantitative proteomics identifies Ola1p as a positive regulator of heat shock response in Saccharomyces cerevisiae
Ola1 is implicated in various stress response pathways, as well as in cancer and tumor progression. However, Ola1p functions are divergent between species and still remain poorly understood. Here, we studied the role of Ola1p in the heat shock response in Saccharomyces cerevisiae. We show that delet...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-02-17 | PXD025587 | Pride
Depletome Heat shock response Proteomics Saccharomyces cerevisiae Native silac 
ProteomicsRsp5/Nedd4 is the major ubiquitin ligase that targets cytosolic misfolded proteins upon heat-stress
The heat-shock response is a complex cellular program that induces major changes in protein translation, folding and degradation to alleviate toxicity caused by protein misfolding. While heat-shock has been widely used to study proteostasis, it remained unclear how misfolded proteins are targeted fo...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2016-07-06 | PXD001214 | Pride
Rsp5 Heat-shock Cytosolic protein quality control 
ProteomicsS. cerevisiae subjected to prolonged heat stress of 37 ºC
Differential proteome composition of wild-type yeast cells (S. cerevisiae BY4741) grown at 30 ºC or 37 ºC was studied using SILAC based quantitative proteomics.
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2015-04-23 | PXD001864 | Pride
Silac. heat stress. proteomics 
ProteomicsQuantitative proteomics identifies Ola1p as a positive regulator of heat shock response in Saccharomyces cerevisiae
Ola1 is implicated in various stress response pathways, as well as in cancer and tumor progression. However, Ola1p functions are divergent between species and still remain poorly understood. Here, we studied the role of Ola1p in the heat shock response in Saccharomyces cerevisiae. We show that delet...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-02-17 | PXD025588 | Pride
Detergent-resistant protein aggregates Proteomics Saccharomyces cerevisiae Native silac 
ProteomicsQuantitative proteomics identifies Ola1p as a positive regulator of heat shock response in Saccharomyces cerevisiae
Ola1 is implicated in various stress response pathways, as well as in cancer and tumor progression. However, Ola1p functions are divergent between species and still remain poorly understood. Here, we studied the role of Ola1p in the heat shock response in Saccharomyces cerevisiae. We show that delet...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-02-17 | PXD026323 | Pride
Detergent-resistant protein aggregates Proteomics Saccharomyces cerevisiae Native silac 
ProteomicsProteomic characterization of Hsp78-interacting proteins highlights chaperone role during protein aggregation in mitochondria under heat stress - Part B Aggregation
Chaperones of the Hsp100 chaperone family support protein homeostasis, the maintenance of protein activity under stress, by refolding aggregated proteins or targeting them for degradation. Hsp78, the ClpB-type mitochondrial member of the Hsp100 family, can be found in lower eukaryotes like yeast. Al...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-09-20 | PXD030436 | Pride
Hsp78 Yeast Cell biology Mitochondria Chaperone Protein aggregation Proteostasis Heat stress 
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