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ProteomicsCharacterization of human plasma depletome from patients with schizophrenia
The proteome of blood plasma is an interesting source of biomarkers and a potential way to improve treatment outcomes in psychiatric disorders. But its wide dynamic concentration range makes reducing its complexity necessary. Thus, in proteomic studies, a few of the most abundant proteins are deplet...
ORGANISM(S): Homo sapiens (Human) 
2019-10-23 | PXD010273 | Pride
Depletion Depletome High-definition mse Proteomics Plasma 
ProteomicsTrypanosoma brucei Mic40 depletome
Molecules that contribute to membrane curvature are essential for the formation of cristae, the bioenergetic subcompartments of mitochondria. Mic60 may be the oldest of these factors as its prokaryotic ortholog is also needed for bioenergetic-subcompartment formation in extant alphaproteobacteria, t...
ORGANISM(S): Trypanosoma brucei 
2025-12-01 | PXD059459 | Pride
Micos Trypanosoma Mitofilin 
UnknownIdentification of chronic brain protein changes and protein targets of serum auto-antibodies after blast-mediated traumatic brain injury.
Not available
S-EPMC7029173 | biostudies-literature
ProteomicsDiverged Trypanosome MICOS as a Hub for Mitochondrial Cristae Shaping and Protein Import
The mitochondrial contact site and cristae organization system (MICOS) is a complex responsible for proper cristae formation. Empirical data about this ubiquitous complex is limited to opisthokont models (e.g. yeast), impeding understanding of its core properties and adaptation potential to diverse ...
ORGANISM(S): Trypanosoma brucei 
2018-09-13 | PXD009601 | Pride
Mitochondria  cristae  intermembrane space  micos  protein import  trypanosoma brucei  lc-ms/ms  label-free  tmt 
ProteomicsMICOS and F1FO-ATP synthase crosstalk is a fundamental property of mitochondrial cristae
Mitochondrial cristae are polymorphic invaginations of the inner membrane that are the fabric of cellular respiration. Both the Mitochondrial Contact Site and Cristae Organization System (MICOS) and the F1FO-ATP synthase are vital for sculpting cristae by opposing membrane bending forces. While MICO...
ORGANISM(S): Trypanosoma brucei brucei TREU927 
2021-06-15 | PXD025109 | Pride
Micos Ip Lc-ms 
ProteomicsQuantitative proteomics identifies Ola1p as a positive regulator of heat shock response in Saccharomyces cerevisiae
Ola1 is implicated in various stress response pathways, as well as in cancer and tumor progression. However, Ola1p functions are divergent between species and still remain poorly understood. Here, we studied the role of Ola1p in the heat shock response in Saccharomyces cerevisiae. We show that delet...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-02-17 | PXD025587 | Pride
Depletome Heat shock response Proteomics Saccharomyces cerevisiae Native silac 
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