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MetabolomicsBiotransformation causes the sex-specific regulation of polychlorinated biphenyls during metamorphosis of silkworm (Bombyx mori) and their effect on the silkworm development

The decline in insect populations is indisputable. Currently, the effects of persistent organic pollutants on insect populations have not been sufficiently investigated. Maternal transfer of pollutants is considered to be an inherently correct reason for sex differences in pollutant le...

2025-09-09 | MTBLS12906 | MetaboLights
TranscriptomicsMicroRNA expression profiling during the life cycle of the silkworm (Bombyx mori)
Background: MicroRNAs (miRNAs) are expressed by a wide range of eukaryotic organisms, and function in diverse biological processes. Numerous miRNAs have been identified in Bombyx mori, but the temporal expression profiles of miRNAs corresponding to each stage transition over the entire life cycle of...
ORGANISM(S): Bombyx mori 
2010-02-20 | E-GEOD-18030 | biostudies-arrayexpress
TranscriptomicsMicroRNAs of Bombyx mori identified by Solexa sequencing
Background: MicroRNA (miRNA) and other small regulatory RNAs contribute to the modulation of a large number of cellular processes. We sequenced three total RNA libraries prepared from the whole body, and the anterior and posterior silk glands of Bombyx mori, with a view to expanding the repertoire o...
ORGANISM(S): Bombyx mori 
2010-02-01 | E-GEOD-17965 | biostudies-arrayexpress
MetabolomicsImaginal disc growth factor maintains cuticle structure and controls melanization in the spot pattern formation of Bombyx mori

The complex stripes and patterns of insects play key roles in behavior and ecology. However, the fine-scale regulation mechanisms underlying pigment formation and morphological divergence remain largely unelucidated. Here we demonstrated that imaginal disc growth factor (IDGF) maintains cuticle s...

2020-09-20 | MTBLS1825 | MetaboLights
MetabolomicsDetoxification metabolic adaptation of Bombyx mori to artificial diet and functional study of key detoxification gene BmGSTd2

The exceptional adaptability of insects to diverse food sources is central to their survival and evolutionary success. However, the molecular mechanisms underlying this rapid adaptation remain largely uncharacterized. In this study, adaptive phenotypic, transcriptomic, and metabolomic differences...

2026-01-27 | MTBLS13782 | MetaboLights
MetabolomicsMetabolomic Microbiome Modulations Induced by ZIF8@ZIF67 Supplementation in the Midgut of Bombyx mori
Bombyx mori is an economically crucial lepidopteran insect, and its health is closely related to the gut microbiota and metabolic status. Our previous research confirmed that metal organic frameworks nanocomposite ZIF8@ZIF67 supplementation can significantly enhance silkworm survival rates upon bact...
2025-05-28 | MTBLS12521 | MetaboLights
MetabolomicsIntegrated transcriptome and metabolome analysis reveals the regulatory mechanism underlying fluoride tolerance in XSKD silkworm strain
XueSong KD (XSKD) is a fluoride-tolerant Bombyx mori strain that grows normally under long-term fluoride exposure, whereas its molecular tolerance mechanism remains elusive. Herein, we performed combined transcriptomic and untargeted metabolomic profiling using pre-molt fourth-instar XSKD larvae fed...
2026-07-07 | MTBLS14966 | MetaboLights
TranscriptomicsMicroRNA expression profiling of the fifth-instar posterior silk gland of Bombyx mori
Background: The growth and development of the posterior silk gland and the biosynthesis of the silk core protein at the fifth larval instar stage of Bombyx mori are of paramount importance for silk production. Results: Here, aided by next-generation sequencing and microarry assay, we profile 1,229 m...
ORGANISM(S): Bombyx mori 
2014-07-30 | E-GEOD-56380 | biostudies-arrayexpress
TranscriptomicsExpression of 50-500nt ncRNAs in silkworm Bombyx mori during two developmental transitions
We have performed the first systematic identification and analysis of intermediate size ncRNAs (50-500 nt) in the silkworm genome. We identified 194 novel ncRNAs, the expression profiles of them during the transitions from the egg to the first instar larva and from the fifth instar larva to the pupa...
ORGANISM(S): Bombyx mori 
2010-12-22 | E-GEOD-22912 | biostudies-arrayexpress
TranscriptomicsMicroRNAs show diverse and dynamic expression patterns in multiple tissues of Bombyx mori
Background: MicroRNAs (miRNAs) repress target genes at the post-transcriptional level, and function in the development and cell-lineage pathways of host species. Tissue-specific expression of miRNAs is highly relevant to their physiological roles in the corresponding tissues. However, to date, few m...
ORGANISM(S): Bombyx mori 
2010-02-20 | E-GEOD-18039 | biostudies-arrayexpress
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