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TranscriptomicsGene expression profiling of ErbB2-engineered MCF10A and WT cells
Gene expression profiling of ErbB2-engineered MCF10A and WT cells in 2D and 3D culture Gene expression profiling of ErbB2-engineered MCF10A and WT cells, 2D and 3D culture, 5 or 6 replicates
ORGANISM(S): Homo sapiens 
2015-09-03 | E-GEOD-62250 | biostudies-arrayexpress
TranscriptomicsIL6-STAT3 downstream targets in MCF10A/MCF10A.ErbB2* cells
Overexpression in IL6 in MCF10A vs. WT, MCF10A.ErbB2* with/without shRNA targeting STAT3 Overexpression in IL6 in MCF10A vs. WT, MCF10A.ErbB* with/without shSTAT3, duplicates, two STAT3 shRNAs
ORGANISM(S): Homo sapiens 
2015-09-03 | E-GEOD-62235 | biostudies-arrayexpress
ProteomicsTriatoma sordida salivary glands LC-MSMS
Triatoma sordida salivary glands secrete a number of complex bioactive proteins during feeding that affect hemostatic and immunological systems from vertebrate hosts. In this study, salivary glands and saliva were collected from 5th instar nymphs and adult triatomines. Liquid chromatography tandem-m...
ORGANISM(S): Triatoma sordida 
2022-02-15 | PXD028350 | Pride
Lc-msms Triatoma sordida Saliva Salivary glands 
UnknownEffect of Combined Treatment with MLC601 (NeuroAiDTM) and Rehabilitation on Post-Stroke Recovery: The CHIMES and CHIMES-E Studies.
Not available
S-EPMC6214602 | biostudies-literature
ProteomicsCK1δ/CK1ε Signaling is Necessary to Sustain mitochondrial Metabolism and Cell Survival in Multiple Myeloma
Multiple myeloma (MM) remains an incurable malignancy due to the acquisition of intrinsic programs that drive therapy resistance. Here we report that casein kinase-1δ (CK1δ) and CK1ε are therapeutic targets for MM that control mitochondrial metabolism. Specifically, SR-3029, a dual CK1δ/CK1ε inhibi...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD025808 | Pride
Mitochondrial metabolism Multiple myeloma Casein kinase Activity-based protein profiling 
ProteomicsABPP of Ibrutinib Resistance in B Cell Malignancies
Ibrutinib,a novel Bruton'styrosine kinase inhibitor, demonstrated high response rates in B-cell lymphomas but a growing number of ibrutinib treated patients relapse with resistance, fulminant progression and accelerated mortality. Using chemical proteomics and a high-throughput ex vivo assay in a re...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD005734 | Pride
Ibrutinib Activity-based protein profiling B-cell cancers Lc-ms/ms 
ProteomicsTriatoma dimidiata salivary glands LC-MSMS
The reduviid bug Triatoma dimidiata is an important Chagas disease vector widely distributed along Central America. This insect has great capability for domestic adaptation as the majority of specimens caught inside human dwellings or in peridomestic areas in Central America fed human blood. Within ...
ORGANISM(S): Triatoma dimidiata 
2018-01-04 | PXD008510 | Pride
Lc-msms Saliva Salivary glands Triatoma dimidiata 
ProteomicsBCL2 amplicon loss and super-enhancer remodeling drives ABT-199 resistance
Drug-tolerant “persister” tumor cells underlie the emergence of drug-resistant clones contribute to relapse and disease progression; thus, identifying actionable targets that disable persisters and mitigate relapse are a high priority need. Although the BCL2-targeting agent venetoclax (ABT-199) has ...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD010193 | Pride
Abpp Lymphoma Persister Apoptosis 
UnknownASPYRE-Lung: validation of a simple, fast, robust and novel method for multi-variant genomic analysis of actionable NSCLC variants in FFPE tissue.
Not available
S-EPMC11461167 | biostudies-literature
UnknownEvaluation of the ASPYRE-Lung targeted variant panel: a rapid, low-input solution for non-small cell lung cancer biomarker testing and experience from three independent sites.
Not available
S-EPMC11632423 | biostudies-literature
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