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DNA methylation is a key epigenetic modification regulating genome organization, stability, and gene expression. Stable DNA methylation critically relies on methyl groups provided through folate-mediated one-carbon (C1) metabolism, yet the origin and regulation of C1 supply remain elusive. Here we d...
2026-01-06 | MTBLS13444 | MetaboLights
The physiology of the planctomycetal anammox bacteria makes them particularly special because they share features with all three domains of life. Anammox bacteria have been reported recently to produce surface-layer proteins, which represent the outermost layer and provide structure, shape and prote...
ORGANISM(S): Candidatus Kuenenia stuttgartiensis Candidatus Brocadia sapporoensis 
2021-08-05 | PXD021600 | Pride
A protein-naming framework was established to determine the relative abundance of both allergens and non-allergenic proteins in 13 different legume seed extracts (roasted peanut, unroasted peanut, soybean, sweet blue lupine, winter pea, beluga lentils, chickpea, field bean, white kidney bean, fenugr...
ORGANISM(S): Cicer arietinum (Chickpea) (Garbanzo) Pisum sativum (Garden pea) Trifolium pratense Glycine max Arachis hypogaea (Peanut) Trigonella foenum-graecum Trifolium repens Medicago sativa (Alfalfa) Lupinus angustifolius Phaseolus vulgaris (Kidney bean) (French bean) Vicia faba Lens culinaris 
2026-10-01 | PXD079632 | Pride
We previously reported that Parkinson’s disease (PD) kinase LRRK2 phosphorylates a subset of Rab GTPases on a conserved residue in their switch-II domains (Steger, Tonelli et al., 2016) (PMID: 26824392). Here, we systematically analyzed the Rab protein family and found 14 of them (Rab3A/B/C/D, Rab5A...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2017-11-14 | PXD007214 | Pride
Dietary restriction (DR) is the best-characterized intervention for slowing aging, and reduced signaling through the target of rapamycin (TOR) kinase is believed to be one of the key mechanisms by which DR extends life span in organisms from yeast to mammals. Here we describe a role for nuclear seq...
ORGANISM(S): Saccharomyces cerevisiae 

Tumor relapse from treatment-resistant cells (minimal residual disease, MRD) underlies most breast cancer related deaths. Yet, the molecular characteristics defining their malignancy have largely remained elusive. Here we integrated multi-omics data from a tractable organoid system with a metabol...

2021-09-14 | MTBLS1507 | MetaboLights
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