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ProteomicsHuman proteomics analysis of BRD4 targeted small-molecules in KSHV+ cells by Orbitrap Eclipse and MaxQuant
In this project, we used proteomics to identify and compare protein profile changed in SIM-1, MZ-1, or JQ-1 treated TIVE-LTC, a KSHV long-term infected immortalized endothelial cell line.
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD075129 | Pride
Brd4 Sim-1 Kshv Mz-1 Jq-1 
UnknownNovel acquired metallo-beta-lactamase gene, bla(SIM-1), in a class 1 integron from Acinetobacter baumannii clinical isolates from Korea.
Not available
S-EPMC1280121 | biostudies-literature
UnknownA bla SIM-1 and mcr-9.2 harboring Klebsiella michiganensis strain reported and genomic characteristics of Klebsiella michiganensis.
Not available
S-EPMC9448873 | biostudies-literature
UnknownSubQ-Sim: A Subcutaneous Physiologically Based Biopharmaceutics Model. Part 1: The Injection and System Parameters.
Not available
S-EPMC10547635 | biostudies-literature
TranscriptomicsThe dependency of cpr5-altered genes on SIM and SMR1 in Arabidopsis
In plants, effector-triggered immunity (ETI) is often associated with programmed cell death (PCD). Although the intracellular immune receptors involved in ETI have been studied extensively, how their activation leads to PCD and disease resistance is poorly understood. We found that the Arabidopsis n...
ORGANISM(S): Arabidopsis thaliana 
2012-12-31 | E-GEOD-40322 | biostudies-arrayexpress
TranscriptomicsSimvastatin Reprograms Lipid Metabolism in B16.F10 Melanoma Cells to Favor an Early Resistant Phenotype
Our previous studies demonstrated that simvastatin (SIM) inhibited B16.F10 murine melanoma cell proliferation in vivo and in vitro via strong suppressing the production of subunit α of hypoxia inducible factor 1 (HIF-1) (HIF-1 α) - a key regulator of cancer cell adaptation to hypoxia. However, beyon...
ORGANISM(S): Mus musculus 
2026-05-04 | GSE329678 | GEO
MetabolomicsMultiomic profiling of medulloblastoma reveals subtype-specific targetable alterations at the proteome and N-glycan level (Metabolite profiling)

Medulloblastomas (MBs) are malignant pediatric brain tumors that are molecularly and clinically very heterogenous. The application of omics technologies - mainly studying nucleic acids - has significantly improved MB classification and stratification, but treatment options are still unsatisfactor...

2024-05-30 | MTBLS9830 | MetaboLights
TranscriptomicsThe dependency of cpr5-altered genes on SIM and SMR1 in Arabidopsis
In plants, effector-triggered immunity (ETI) is often associated with programmed cell death (PCD). Although the intracellular immune receptors involved in ETI have been studied extensively, how their activation leads to PCD and disease resistance is poorly understood. We found that the Arabidopsis n...
ORGANISM(S): Arabidopsis thaliana 
2012-12-31 | GSE40322 | GEO
GenomicsGenomic analyses of H1 cells induced by FOXO1
Insufficient understanding on cold adaptation technically restricts donor tissue banking. Here we identify FOXO1 as a conserved transcription factor for cell cold survival, relocating from cytosol to nucleus when temperature drops. FOXO1 small ubiquitin-like modifiers (SUMO) -interacting motif (SIM)...
ORGANISM(S): Homo sapiens 
2024-03-01 | GSE183998 | GEO
TranscriptomicsPolycomb Repressive Complex 1 subunit Cbx4 positively regulates effector responses in CD8 T cells
Cytotoxic T lymphocyte (CTL) differentiation is controlled by the crosstalk of various transcription factors and epigenetic modulators. Fully uncovering this process is fundamental to improving immunotherapy and designing novel therapeutic approaches. Here, we show that Polycomb Repressive Complex (...
ORGANISM(S): Mus musculus 
2023-07-10 | GSE236487 | GEO
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