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ProteomicsProteomic Analysis of the Effects of Simulated Microgravity in GES-1 Cells
Microgravity is an ecological factor that affect the environment of the body. In this study, quantitative isobaric labeling (tandem mass tag) methods were used to study the changes in human gastric mucosal cells under simulated microgravity.
ORGANISM(S): Homo sapiens (Human) 
2022-03-03 | PXD026675 | Pride
Ges-1 cells lc-ms/ms simulated microgravity 
TranscriptomicsGlobal gene expression profiles of cardiac progenitors differentiated from human pluripotent stem cells in 3D culture under simulated microgravity
Methods: RNA-seq libraries were prepared using the Illumina TruSeq RNA kit and the TrueSeq method was employed for mRNA enrichment. The libraries were quantified and samples were multiplexed in each lane of the flowcell. Cluster generation was performed and then sequenced on the Illumina HiSeq1000 s...
ORGANISM(S): Homo sapiens 
2016-08-08 | E-GEOD-84582 | biostudies-arrayexpress
ProteomicsProteomics of intestine in simulated microgravity rats
After 14 days simulated microgravity，rats jejunal mucosa was taken for proteomic study. A total of 1826 proteins were detected, and 335 differentially expressed proteins were detected, of which 190 were up-regulated and 145 were down-regulated.
ORGANISM(S): Rattus Norvegicus 
2020-09-17 | PXD021522 |
ProteomicsSimulated microgravity-induced changes in SUMOylation and protein expression in Saccharomyces cerevisiae
This study investigated the impact of simulated microgravity (SMG) on SUMOylation and protein expression in Saccharomyces cerevisiae. Utilizing a rotating wall vessel to simulate microgravity conditions, the research employed SILAC labeling and bottom-up proteomics to differentiate gravity vs SMG fo...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-01-19 | PXD070877 | Pride
Rotating wall vessels Silac Simulated microgravity Proteomics Saccharomyces cerevisiae 
TranscriptomicsHuman Peripheral Blood Lymphcoyte(PBL): Simulated Microgravity vs. Control
Transcriptional profiling of human peripheral blood lymphocyte comparing simulated microgravity for 72 hours with untreated control. Two-condition experiment, simulated microgravity vs.untreated control. Biological replicates: 1 control, 1 treated, independently grown and harvested.
ORGANISM(S): Homo sapiens 
2014-04-10 | E-GEOD-56647 | biostudies-arrayexpress
ProteomicsComparative proteomic analysis and bioluminescent reporter gene assays to investigate effects of simulated microgravity on Caco-2 cells
Microgravity is one of the most important features in spaceflight. Previous evidence has shown that significant changes to the musculoskeletal and immune systems occurred under microgravity. The present study was undertaken to explore the change in protein abundance in human colon colorectal cells ...
ORGANISM(S): Homo sapiens (Human) 
2017-07-26 | PXD005823 | Pride
Simulated microgravity Nuclear factor κ-b Caco-2 cells Reporter gene technology Label-free proteomics Bioluminescence 
Proteomics1 Enhanced assembly of bacteriophage T7 produced in cell-free reactions under simulated microgravity
On-demand biomanufacturing has the potential to improve healthcare and self- sufficiency during space missions. Cell-free transcription and translation reactions combined with DNA blueprints can produce promising therapeutics like bacteriophages and virus-like particles. However, how space condition...
ORGANISM(S): Escherichia coli 
2024-03-13 | PXD044176 | Pride
T7 phage Proteomics Microgravity 
ProteomicsHuman bone marrow stromal cells under simulated microgravity ' bottom-up, label free, shot gun approach in DIA
A multidisciplinary approach was employed to characterize morphological, biochemical and molecular changes underlying the human BMSCs response to simulated microgravity exposure during osteogenic differentiation.
ORGANISM(S): Homo sapiens (Human) 
2022-10-02 | PXD033475 | Pride
Microgravity  human bmscs  bottom-up 
Transcriptomicsaction of microgravity on root development-Action of microgravity on root development
au11-03_gravite - action of microgravity on root development - Action of microgravity on root development - Arabidopsis were grown on horizontal or vertical clinostat for 4, 8 or 12 days. Seedlings on horizontal clinostat were in simulated microgravity and seedlings on vertical clinostat are conside...
ORGANISM(S): Arabidopsis thaliana 
2012-07-31 | E-GEOD-39631 | biostudies-arrayexpress
ProteomicsThe influence of simulated microgravity on the proteome of Daphnia magna
Background/Objectives: The waterflea Daphnia is an interesting candidate for biore- generative life support systems (BLSS). These animals are particularly promising be- cause of their central role in the limnic food web and its mode of reproduction. How- ever, the response of Daphnia to altered grav...
ORGANISM(S): Daphnia magna 
2015-09-08 | PXD002096 | Pride
Functional weightlessness Bioregenerative life support system Daphnia Clinorotation Proteomics 
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