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TranscriptomicsSimple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
Genome-scale studies have revealed extensive co-localization of transcription factors in a given cell type as well as substantial differences in the binding patterns of specific transcription factors between cell types. Several mechanisms have been proposed to explain these observations, including t...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-21512 | biostudies-arrayexpress
GenomicsTranscriptional regulation of germinal center B and plasma cell fates by dynamical control of IRF4 (ChIP-seq)
Temporal analysis of Irf4 and PU.1 genome binding during B cell activation and differentiation in vitro using antigen (NP-Ficoll) CD40L and IL-2/4/5 cytokines (see Molecular Systems Biology 7:495 for details of cellular system). The results provide insight in the target genes and binding specificity...
ORGANISM(S): Mus musculus 
2013-05-04 | E-GEOD-46607 | biostudies-arrayexpress
ProteomicsMetabolomics Integration with Gene expression profiling Elucidates IL4I1 as Modulator of Ibrutinib Resistance in ABC large B cell Lymphoma
Drug resistant acute B-cell lymphoma cells were analyzed via LC-MS metabolomics to identify deregulated metabolic pathways that are associated with drug resistance.
ORGANISM(S): Human 
2021-03-16 | MSV000087059 | MassIVE
ProteomicsSite-specific profiling of structure and function of IgM B cell receptor glycans
Although N-linked glycans play pivotal roles in the regulation of antibody effector functions, little is known about the composition and functional impact of glycans expressed by human B cell receptors (BCRs), likely due to technical challenges. Here, we describe the site-specific glycosylation prof...
ORGANISM(S): Homo sapiens (Human) 
2025-12-09 | PXD062559 | Pride
Igm Primary naïve and memory b cells N-linked glycosylation Human b cell receptors 
TranscriptomicsSingle cell RNA-sequencing of PBMC derived B cells from human healthy donor
Motivation: The B-cell receptor (BCR) performs essential functions for the adaptive immune system including recognition of pathogen-derived antigens. The vast repertoire and adaptive variation of BCR sequences due to V(D)J recombination and somatic hypermutation (SHM) necessitates single-cell charac...
ORGANISM(S): Homo sapiens 
2018-06-22 | E-MTAB-6386 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of TIL rich HPV driven head and neck tumours reveals a distinct B-cell signature when compared to HPV independent tumours.
Purpose: Human papilloma virus (HPV) associated head and neck squamous cell carcinoma (HNSCC) has a better prognosis than HPV(-) negative cancer. This may be due, in part, to the higher number of tumour infiltrating lymphocytes (TIL) in HPV(+) tumours. We used RNAseq to evaluate whether these differ...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-72536 | biostudies-arrayexpress
TranscriptomicsRegulation of bifurcating B cell trajectories by mutual antagonism between IRF4 and IRF8 (RNA-Seq)
Upon antigen recognition B cells undertake a bifurcated response in which some cells rapidly differentiate into plasmablasts while others undergo affinity maturation in germinal centers (GC). We uncover a double negative feedback loop between interferon regulatory factors IRF4 and IRF8, which regula...
ORGANISM(S): Mus musculus 
2015-08-25 | E-GEOD-70711 | biostudies-arrayexpress
GenomicsRegulation of bifurcating B cell trajectories by mutual antagonism between IRF4 and IRF8 (ChIP-Seq)
Upon antigen recognition B cells undertake a bifurcated response in which some cells rapidly differentiate into plasmablasts while others undergo affinity maturation in germinal centers (GC). We uncover a double negative feedback loop between interferon regulatory factors IRF4 and IRF8, which regula...
ORGANISM(S): Mus musculus 
2015-08-25 | E-GEOD-70710 | biostudies-arrayexpress
ProteomicsTargeting G1–S Checkpoint–Compromised Cancers with Cyclin A/B RxL Inhibitors
Cancer cell proliferation requires precise control of E2F1 activity; excess activity promotes apoptosis. Here, we developed cell-permeable and bioavailable macrocycles that selectively kill small cell lung cancer (SCLC) cells with inherent high E2F1 activity by blocking RxL-mediated interactions of ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-30 | PXD055112 | Pride
Macrocycle Cyclin a E2f Cyclin b Cy/rxl motif Cdk2 Sac Synthetic lethality 
GenomicsGenome-wide binding map of FoxO1 and Pax5 in pre-B cells
Genome-wide analysis of FoxO1 and Pax5 binding in pre-B cells following attenuation of IL-7 signaling. Transcription factor FoxO1 has been shown to be an essential factor for Ig light chain rearrangement. Results demonstrate that FoxO1 and Pax5 co-target genes that are activated during pre-B cell di...
ORGANISM(S): Mus musculus 
2012-01-12 | E-GEOD-35024 | biostudies-arrayexpress
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