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MetabolomicsBacteroides acidifaciens Derived Succinate Mediates Gynostemma pentaphyllum Polysaccharides' Effects on Muscle Fiber Switching and Exercise Endurance

Enhancing exercise endurance holds significant practical implications for boosting the physical fitness of the general population to address daily challenges and improving the physical capabilities and quality of life of patients with relevant diseases. Polysaccharides from Gynostemma pentaphyllu...

2025-10-28 | MTBLS13229 | MetaboLights
ProteomicsHigh-throughput Proteomics fiber typing (ProFiT) for comprehensive characterization of single skeletal muscle fibers
Skeletal muscles are composed of a heterogeneous collection of fiber types with different physiological adaption in response to a stimulus and disease-related conditions. Each fiber has a specific molecular expression of myosin heavy chain molecules (MyHC). So far MyHCs are currently the best marker...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-02 | PXD017755 | Pride
Muscle fiber proteomics Protein turnover Phosphoproteomics Myhc profiling 
ProteomicsSingle muscle fiber proteomics reveals fiber type-specific features of human muscle aging
Skeletal muscle is a key tissue in human aging, which affects different muscle fiber types unequally. We developed a highly sensitive single muscle fiber proteomics workflow to study human aging and show that the senescence of slow and fast muscle fibers is characterized by diverging metabolic and p...
ORGANISM(S): Homo sapiens (Human) 
2017-06-14 | PXD006182 | Pride
Muscle fibers Skeletal muscle Aging 
MetabolomicsMulti-omics Insights into Postnatal Skeletal Muscle Development in Duroc Pigs

Skeletal muscles, accounting for 40% of mammalian body mass, exhibit pronounced heterogeneity due to distinct anatomical locations. Animal husbandry excessively focuses on longissimus dorsi (LDM) development, while neglecting other muscles. In this study, we integrated Bulk RNA Sequencing (bulk R...

2025-09-09 | MTBLS12963 | MetaboLights
MetabolomicsClenbuterol exerts antidiabetic activity through metabolic reprogramming of skeletal muscle cells
Activation of the sympathetic nervous system causes pronounced metabolic changes that are mediated by multiple adrenergic receptor subtypes. Systemic treatment with β2-adrenergic receptor agonists results in multiple beneficial metabolic effects, including improved glucose homeostasis. To...
2022-08-26 | MTBLS467 | MetaboLights
ProteomicsSingle muscle fiber proteomics reveals remodeling of focal adhesions in response to muscle unloading and microgravity
Spaceflight causes loss of muscle mass and strength, metabolic remodeling and insulin resistance, contributing to severe challenges for astronaut health. We used highly sensitive proteomics to detail single fiber type-specific molecular remodeling caused by muscle unloading in subjects undergoing pr...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD028435 | Pride
Proteomics Microgravity Muscle 
ProteomicsSingle muscle fiber proteomics reveals unexpected mitochondrial specialization
Mammalian skeletal muscles are composed of multinucleated cells termed slow or fast fibers according to their contractile and metabolic properties. Here we developed a high sensitivity workflow to characterize the proteome of single fibers. Analysis of segments of the same fiber by traditional and u...
ORGANISM(S): Mus musculus (Mouse) 
2015-02-05 | PXD001641 | Pride
Metabolism Muscle fibers Single cell Exercise Mitochondria 
MetabolomicsSerine synthesis pathway enzyme PHGDH is critical for muscle cell biomass, anabolic metabolism and mTORC1 signaling

Cells use glycolytic intermediates for anabolism e.g., via the serine synthesis and pentose phosphate pathways. However, we still understand poorly how these metabolic pathways contribute to skeletal muscle cell biomass generation. The first aim of this study was therefore to identify enzymes tha...

2025-03-21 | MTBLS8854 | MetaboLights
TranscriptomicsHoxd genes and fiber type-specific markers specify adult mouse muscle type in a diet-independent way
Introduction: The mouse skeletal muscle is composed of four distinct fiber types that differ in contractile function, number of mitochondria and metabolism. Every muscle group has a specific composition and distribution of the four fiber types. Until now, three genes (CnA, PGC1α and PPARδ) are ident...
ORGANISM(S): Mus musculus 
2010-09-03 | E-GEOD-18127 | biostudies-arrayexpress
MetabolomicsPEROXISOMAL-MITOCHONDRIAL INTERPLAY ALTERATIONS IN SKELETAL MUSCLE RESULT IN EARLY-ONSET SARCOPENIA

Adjustments in muscle mass and metabolic demand are crucial for regulating whole-body metabolism, locomotion, eating, and respiration. Therefore, skeletal muscle is a central influencer of several human diseases. Muscle dysfunction correlates with the onset and progression of several metabolic di...

2025-09-15 | MTBLS12833 | MetaboLights
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