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ProteomicsTriazolinedione protein modification: from an overlooked off-target effect to a tryptophan-based bioconjugation strategy
Labelling of tyrosine residues in peptides and proteins has been reported to selectively occur via a 'tyrosine-click' reaction with triazolinedione reagents (TAD). However, we here demonstrate that TAD reagents are actually not selective for tyrosine and that tryptophan residues are in fact also lab...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD031607 | Pride
Site-selective protein modification Tad Tryptophan Protein modification 
ProteomicsSite-Selective Photocatalytic Functionalization of Peptides and Proteins at Selenocysteine
The importance of modified peptides and proteins for applications in drug discovery, and for illuminating biological processes at the molecular level, has fueled a demand for efficient methods that facilitate the precise modification of these biomolecules. Herein, we describe the development of a ph...
ORGANISM(S): Homo sapiens (Human) 
2022-10-25 | PXD037525 | Pride
Selenocysteine Modification 
UnknownSite-Selective Protein Modification via Peptide-Directed Proximity Catalysis.
Not available
S-EPMC12756790 | biostudies-literature
UnknownCalibrating Catalytic DNA Nanostructures for Site-Selective Protein Modification.
Not available
S-EPMC9546015 | biostudies-literature
ProteomicsSite-Selective Protein Conjugation by a Multicomponent Ugi Reaction
The chemical bioconjugation of proteins has seen tremendous applications in the past decades, with the booming of antibody-drug conjugates and their use in oncology. While genetic engineering has permitted to produce bespoke proteins featuring key (un-)natural amino acid residues poised for site-sel...
ORGANISM(S): Homo sapiens (Human) 
2024-09-09 | PXD045387 | Pride
Biomolecule  site conjugation  chemical biology  peptide mapping 
UnknownSite-selective protein conjugation at histidine.
Not available
S-EPMC6354831 | biostudies-literature
GenomicsChIP-seq analysis of H3K27me3 histone modification in EZH2 mutant and wild type DLBCL cell lines
In eukaryotes, epigenetic post-translational modification of histones is critical for regulation of chromatin structure and gene expression. EZH2 is the catalytic subunit of the Polycomb Repressive Complex 2 (PRC2) and is responsible for repressing target gene expression through methylation of histo...
ORGANISM(S): Homo sapiens 
2012-10-12 | E-GEOD-40970 | biostudies-arrayexpress
ProteomicsSite-specific mapping and quantification of protein S-sulphenylation in cells

Jing Yang, Vinayak Gupta, Kate S. Carroll, & Daniel C. Liebler, (2014) Nature Communications 5, 4776, doi:10.1038/ncomms5776

Cysteine S-sulphenylation provides redox regulation of protein f...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-08-28 | MSV000084244 | MassIVE
UnknownBind&Bite: covalently stabilized heterodimeric coiled-coil peptides for the site-selective, cysteine-free chemical modification of proteins.
Not available
S-EPMC10549240 | biostudies-literature
UnknownSite-Selective Peptide and Protein Functionalization with Cyclopropenium Cations.
Not available
S-EPMC12723463 | biostudies-literature
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