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MetabolomicsMetabolic Reprogramming and Reliance in Human Skin Wound Healing
Impaired skin wound healing is a significant global health issue, especially among the elderly. Wound healing is a well-orchestrated process involving the sequential phases of inflammation, proliferation, and tissue remodeling. Although wound healing is a highly dynamic and energy-requiring process,...
2024-07-02 | MTBLS3315 | MetaboLights
TranscriptomicsTranscription profiling of human grafted engineered skin substitutes compared with intact human
The goal of the experiment: To characterize the dynamic gene expression profile of engineered human skin in vitro and after grafting, and compare with expression profile of uninjured human skin. Bioengineered skin substitutes can facilitate wound closure in massively burned patients, but deficiencie...
ORGANISM(S): Homo sapiens 
2009-09-07 | E-GEOD-17539 | biostudies-arrayexpress
TranscriptomicsHeparan sulfate in skin wounds
Standardized skin wounds were established surgically on mice and allowed to heal during a 15-day period. Expression of genes related to heparan sulfate biosynthesis was studied in wound bed and edges during the healing process. Total RNA was isolated from wound edge (regenerating skin) and wound be...
ORGANISM(S): Mus musculus 
2010-05-22 | E-GEOD-7435 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of a wound healing process in skin and oral mucosa
When compared to skin, oral mucosal wounds heal rapidly and with reduced scar formation. This study used an Affymetrix microarray platform to compare the transcriptomes of oral mucosa and skin wounds in order to identify critical differences in the healing response at these two sites. Using microarr...
ORGANISM(S): Mus musculus 
2010-07-20 | E-GEOD-23006 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human native skin, cultured skin substitute, constituent keratinocytes and fibroblasts to identify gene signatures that are highly characteristic of different tissue types
Cultured skin substitutes, prepared using keratinocytes, fibroblasts and biopolymers, can facilitate closure of massive burn wounds by increasing the availability of autologous tissue for grafting. However, because they contain only two cell types, skin substitutes cannot replace all of the functio...
ORGANISM(S): Homo sapiens 
2007-09-06 | E-GEOD-3204 | biostudies-arrayexpress
ProteomicsEffect of burn wound treatment with fish skin on mouse skin proteome
This study explored the feasibility of using fish skin bandages as a therapeutic option for third-degree skin burns. Following the California wildfires, clinical observations of animals with third-degree skin burns demonstrated increased comfort levels and reduced pain when treated with tilapia fish...
ORGANISM(S): Mus Musculus 
2024-03-11 | PXD050514 | panorama
ProteomicsSkin proteomics reveals the potential mechanism of AgNCs-hydrogel in promoting the regeneration of diabetic infectious wounds
Diabetic infectious wounds treatment is challenging due to insistent wound infections. Treating such complicated pathological diabetic infectious wounds needs to develop multifunctional materials and understand their mechanism. Here, we developed a novel material termed AgNCs-hydrogel, which is a mu...
ORGANISM(S): Mus Musculus 
2023-08-07 | PXD044438 |
ProteomicsA multi-omics analysis identifies retinol metabolism in fibroblasts as a key pathway in wound healing
In this project, we analysed the proteome of skin wounds to investigate whether a vitamin A-deficient diet influences the wound proteome. To achieve this, we conducted quantitative, unbiased proteomic analysis using data-independent acquisition (DIA) mass spectrometr using skin wounds lysates.
ORGANISM(S): Mus musculus (Mouse) 
2025-09-30 | PXD061167 | Pride
Dia Lc-ms Skin wounds 
GenomicsTranscriptional profiling of macrophages in skin wounds
Transcriptional profiling of macrophages in skin wounds
PRJNA761021 | ENA
GenomicsTranscriptomic analysis of unwounded skin, vehicle-treated wounds, and brequinar-treated wounds in mice
Transcriptomic analysis of unwounded skin, vehicle-treated wounds, and brequinar-treated wounds in mice
PRJNA1490817 | ENA
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