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Unknown4-1BBL-containing leukemic extracellular vesicles promote immunosuppressive effector regulatory T cells.
Not available
S-EPMC8941461 | biostudies-literature
UnknownBCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance.
Not available
S-EPMC1895841 | biostudies-literature
Proteomicsproteomic profiling of small extracellular vesicles (EVs), released by chronic myeloid leukemia cells K562
Chronic and acute myeloid leukemia (CML/AML) evade immune surveillance and induce immunosuppression, largely by upregulating Foxp3+ regulatory T cells (Treg). However, mechanisms that drive Treg in myeloid leukemias are largely unknown. Here, we show that leukemic (CML- and AML-derived) extracellula...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD027240 | Pride
Leukemia K562 Extracelluar vesicles Evs 
UnknownAssociations between injury occurrence and environmental temperatures in the Australian and German professional football leagues.
Not available
S-EPMC11756877 | biostudies-literature
ProteomicsPARG is Essential for Pol-theta-Mediated DNA End-Joining by Removing Repressive Poly-ADP Ribose Marks
DNA polymerase theta (Pol-theta)-mediated end-joining (TMEJ) repairs DNA double-strand breaks and confers resistance to genotoxic agents. How Pol-theta is regulated at the molecular level to exert TMEJ remains unknown. We find that Pol-theta interacts with and is PARylated by PARP1 in vitro and in c...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000092839 | MassIVE
ProteomicsTIAR and FMRP shape pro-survival nascent proteome of leukemia cells in the bone marrow microenvironment
Chronic myeloid leukemia (CML) cells circulate between blood and bone marrow niche, representing different microenvironments. We studied the role of the two RNA binding proteins, T-cell-restricted intracellular antigen (TIAR) and the fragile X mental retardation protein (FMRP) in the regulation of p...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD032332 | Pride
Quancat Fmrp Chronic myeloid leukemia Tiar 
UnknownAKT-induced reactive oxygen species generate imatinib-resistant clones emerging from chronic myeloid leukemia progenitor cells.
Not available
S-EPMC4262587 | biostudies-literature
UnknownSimultaneous Inhibition of BCR-ABL1 Tyrosine Kinase and PAK1/2 Serine/Threonine Kinase Exerts Synergistic Effect against Chronic Myeloid Leukemia Cells.
Not available
S-EPMC6826736 | biostudies-literature
UnknownChronic myeloid leukemia: mechanisms of blastic transformation.
Not available
S-EPMC2898591 | biostudies-literature
UnknownTIAR and FMRP shape pro-survival nascent proteome of leukemia cells in the bone marrow microenvironment.
Not available
S-EPMC10140000 | biostudies-literature
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