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ProteomicsOxygen-dependent regulation of E3(SCF)ubiquitin ligases and a Skp1-associated JmjD6 homolog in Dictyostelium
The SCF (Skp1/cullin-1/F-box protein) class of E3 polyubiquitin ligases generates a signal for proteasomal degradation of thousands of proteins in animals. The evolutionary diversification of the F-box protein (FBP) family of substrate receptor subunits has challenged elucidation of these complexes ...
ORGANISM(S): Dictyostelium discoideum (Slime mold) 
2022-07-22 | PXD033864 | Pride
Lc-msms Glycosylation Dictyostelium Skp1 Scf Immunoprecipitation E3 
ProteomicsThe endosomal TbTpr86/TbUsp7/SkpZ (TUS) complex controls surface protein abundance in trypanosomes
In trypanosomes two deubiquitilating enzymes (DUBs), orthologous to human USP7 and VDU1, control abundance of a cohort of surface proteins, including invariant surface glycoproteins (ISGs). Silencing TbUsp7 partially inhibits endocytosis and invariant surface glycoprotein turnover. S-phase kinase-as...
ORGANISM(S): Trypanosoma brucei 
2025-01-08 | PXD021000 | Pride
Ubiquitylation Skp1 Trypanosoma brucei Surface proteome Tus complex Cullin e3 ligase Usp7 
GenomicsCovalent targeting of the SKP1-βTrCP interface activates NRF1/2 signaling [IMR32]
Covalent targeting of the SKP1-βTrCP interface activates NRF1/2 signaling [IMR32]
PRJNA1537519 | ENA
GenomicsCovalent targeting of the SKP1-βTrCP interface activates NRF1/2 signaling [HepG2]
Covalent targeting of the SKP1-βTrCP interface activates NRF1/2 signaling [HepG2]
PRJNA1537520 | ENA
ProteomicsThe SKP1-PPM1B axis regulates the switch between autophagy and unconventional secretion
SKP1, an essential subunit of the SKP1-CUL1-F-box protein (SCF) complex, also known as CUL1-RING ubiquitin ligase (CRL1), a family of E3s present in all eukaryotes, which includes 69 members in humans that mediates the proteasomal degradation of hundreds of cellular regulatory proteins. Here we fou...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-11-10 | MSV000090691 | MassIVE
UnknownGlycosylation of Skp1 promotes formation of Skp1-cullin-1-F-box protein complexes in dictyostelium.
Not available
S-EPMC4288264 | biostudies-literature
ProteomicsImmunoprecipitation followed by mass spectropmetry of Plasmodium falciparum Skp1
This study is aim to characterize Plasmodium falciparum Skp1 to find its interacting partners.
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2024-02-14 | PXD040194 | Pride
Skp1 Ip-ms Plasmodium 
UnknownOxygen-dependent regulation of F-box proteins in Toxoplasma gondii is mediated by Skp1 glycosylation.
Not available
S-EPMC11570480 | biostudies-literature
ProteomicsA noncanonical function of SKP1 regulates the switch between autophagy and unconventional secretion
Intracellular degradation of proteins and organelles by the autophagy-lysosome system is essential for cellular quality control and energy homeostasis. Besides degradation, endolysosomal organelles can fuse with the plasma membrane and contribute to unconventional secretion. Here, we identify a func...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-07-06 | MSV000092361 | MassIVE
ProteomicsMass spectrometry analysis of the Skp1 and Cullin1 interactome in Leishmania infantum
Leishmania infantum is the causative agent of visceral leishmaniasis in Latin America, a lethal disease if misdiagnosed or left untreated. The ubiquitin proteasome system (UPS) is the main regulator of intracellular proteolysis in eukaryotes and is required for parasite's to life cycle and infectio...
ORGANISM(S): Leishmania infantum 
2024-07-01 | PXD051961 | Pride
Ap-ms Cullin-1-ring ubiquitin ligases (crl1) E3 ubiquitin ligases Leishmania infantum 
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