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ProteomicsIdentification of SLFN5 as an intrinsic inhibitor of viral transcription antagonized by the herpes simplex virus ubiquitin ligase ICP0
Intrinsic antiviral host factors are proteins that can confer cellular defense by limiting virus replication. Viruses hijack ubiquitin machinery to modify the cellular proteome to subvert these host defenses. The herpes simplex virus 1 (HSV-1) expresses ICP0, which functions as an E3 ubiquitin ligas...
ORGANISM(S): Homo sapiens (Human) Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) Human alphaherpesvirus 1 
2020-09-14 | PXD018773 | Pride
Dicp0 Herpes simplex virus Slfn5 Ipond Hsv-1 Ubiquitin Icp0 
TranscriptomicsRegulatory Role of SLFN5 in Type I Interferon Signaling
We provide evidence that a member of the IFN-regulated member of the Schlafen (SLFN) family of proteins, SLFN5, promotes the malignant phenotype in glioblastoma multiforme (GBM). Our studies demonstrate that SLFN5 negatively regulates expression of key interferon stimulated genes (ISGs) that mediate...
ORGANISM(S): Homo sapiens 
2017-01-31 | GSE88771 | GEO
UnknownSLFN5 promotes reversible epithelial and mesenchymal transformation in ovarian cancer.
Not available
S-EPMC9901157 | biostudies-literature
ProteomicsSchlafen family member 5 (SLFN5) regulates LAT1-mediated mTOR activation in castration-resistant prostate cancer (PART 2)
Androgen-deprivation therapy (ADT) is the standard of care for the treatment of non-resectable prostate cancer (PCa). Despite high treatment efficiency, most patients ultimately develop lethal castration-resistant prostate cancer (CRPC). In this study, we perform a comparative proteomic analysis of ...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD021405 | Pride
Castration-resistant prostate cancer Lat1/mtor signalling Cancer metabolism Proteomics 
GenomicsSchlafen 5 (SLFN5) is an Intracellular Immune Checkpoint and controls Interferon (IFN) Responses in Pancreatic Ductal Adenocarcinoma (PDAC)
Schlafen 5 (SLFN5) is an Intracellular Immune Checkpoint and controls Interferon (IFN) Responses in Pancreatic Ductal Adenocarcinoma (PDAC)
PRJNA1191415 | ENA
TranscriptomicsHuman Schlafen 5 (SLFN5) is a Regulator of Motility and Invasiveness of Renal Cell Carcinoma (RCC) Cells
There is some emerging evidence that members of the Schlafen (SLFN) family of proteins mediate antineoplastic responses, but the mechanisms accounting for these effects are not known. We provide evidence that human SLFN5, an interferon (IFN)- inducible member of the family, exhibits key roles in con...
ORGANISM(S): Homo sapiens 
2015-06-01 | GSE64399 | GEO
TranscriptomicsSchlafen 5 (SLFN5) is an Intracellular Immune Checkpoint and controls Interferon (IFN) Responses in Pancreatic Ductal Adenocarcinoma (PDAC)
We provide evidence that human and murine SLFN5 proteins are modulators of Type I IFN responses and the immune response in pancreatic cancer. Blocking expression of Slfn5 in PDAC enhances IFN-responses, suppresses tumor growth, and prolongs survival in immunocompetent mice. Notably, immunophenotypic...
ORGANISM(S): Homo sapiens 
2026-01-14 | GSE282985 | GEO
UnknownHuman SLFN5 and its Xenopus Laevis ortholog regulate entry into mitosis and oocyte meiotic resumption.
Not available
S-EPMC9729291 | biostudies-literature
UnknownHuman Schlafen 5 (SLFN5) Is a Regulator of Motility and Invasiveness of Renal Cell Carcinoma Cells.
Not available
S-EPMC4524119 | biostudies-literature
UnknownKnockdown of Slfn5 alleviates lipopolysaccharide-induced pneumonia by regulating Janus kinase/signal transduction and activator of transcription pathway.
Not available
S-EPMC10797344 | biostudies-literature
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