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GenomicsMuTHER adipose tissue small RNA expression
We investigate the naturally occurring variation of small RNA expression in conjunction with genetic and gene expression variation. We shall assess the variation in subabdominal fat tissue small RNA levels in 168 unrelated MuTHER individuals. Using gene expression data from the same samples, we can ...
EGAS00001000212 | EGA
TranscriptomicsFunction, targets and evolution of Caenorhabditis elegans piRNAs (small RNA-Seq)
piRNAs are required to maintain germline integrity and fertility but their mechanism of action is poorly understood. Here we demonstrate that C. elegans piRNAs silence transcripts in trans through imperfectly complementary sites. We find that target silencing is independent of Piwi endonuclease acti...
ORGANISM(S): Caenorhabditis elegans 
2012-06-18 | E-GEOD-28617 | biostudies-arrayexpress
MetabolomicsLeptin increases hepatic triglyceride export via a vagal mechanism in humans
Recombinant human leptin (metreleptin) reduces hepatic lipid content in patients with lipodystrophy and overweight patients with non-alcoholic fatty liver disease and relative hypoleptinemia independent of its anorexic action. In rodents, leptin signaling in the brain increases very-low-density lipo...
2023-06-07 | MTBLS4231 | MetaboLights
GenomicsEGAS00001000212-sc-20120201 - samples
MuTHER adipose tissue small RNA expression
EGAD00001000105 | EGA
TranscriptomicspiRNAs can trigger a multigenerational epigenetic memory in the germline of C. elegans
Transgenerational effects likely have wide-ranging implications for human health, biological adaptation and evolution, however their mechanism and biology remain poorly understood. Here we demonstrate that a germline nuclear small RNA/chromatin pathway can maintain epi-allelic inheritance for many g...
ORGANISM(S): Caenorhabditis elegans 
2012-06-25 | E-GEOD-38813 | biostudies-arrayexpress
TranscriptomicsMCMV infection of cultured mouse cells induces expression of miR-7a.
One goal of viral infection is to reprogram the host cell to optimize viral replication. As part of this process, viral miRNAs may compete for components of the miRNA/siRNA pathway as well as regulate cellular targets. Mouse Cytomegalovirus has been described to generate large numbers of viral miRNA...
ORGANISM(S): Mus musculus 
2012-06-30 | E-GEOD-36919 | biostudies-arrayexpress
UnknownThe Mutational Landscape of Early-Onset Breast Cancer: A Next-Generation Sequencing Analysis.
Not available
S-EPMC8813959 | biostudies-literature
ProteomicsHigh-Content Screening Identifies A Small Molecule That Restores AP-4-dependent Protein Trafficking In Neuronal Models Of AP-4-Associated Hereditary Spastic Paraplegia
Unbiased phenotypic screens in patient-relevant disease models offer the potential to detect therapeutic targets for rare diseases. In this study, we developed a high-throughput screening assay to identify molecules that correct aberrant protein trafficking in adaptor protein complex 4 (AP-4) defici...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD042950 | Pride
Human Autophagy Ipsc Drug screen Protein trafficking Hsp 
UnknownGermline ERBB3 mutation in familial non-small-cell lung carcinoma: expanding ErbB's role in oncogenesis.
Not available
S-EPMC8643496 | biostudies-literature
MetabolomicsGut microbiome dysbiosis drives metabolic dysfunction in Familial dysautonomia
Familial dysautonomia (FD) is a rare genetic neurologic disorder caused by impaired neuronal development and progressive degeneration of both the peripheral and central nervous systems. FD is monogenic, with >99.4% of patients sharing an identical point mutation in the elongator acetyltransferase co...
2022-12-06 | MTBLS5138 | MetaboLights
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