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MetabolomicsConnecting structure and function from organisms to molecules in small-animal symbioses through chemo-histo-tomography
Our understanding of metabolic interactions between small symbiotic animals and bacteria or parasitic eukaryotes that reside within their bodies is extremely limited. This gap in knowledge originates from a methodological challenge, namely to connect histological changes in host tissues induced by b...
2021-07-06 | MTBLS2639 | MetaboLights
ProteomicsLocal RNA translation controls cell migration and Rab GTPase function
Numerous RNAs exhibit specific distribution patterns in mammalian cells. However, the functional and mechanistic consequences are relatively unknown. We investigate here the functional role of RNA localization at cellular protrusions of mesenchymal migrating cells, using as a model the RAB13 RNA, wh...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-08-01 | MSV000085883 | MassIVE
TranscriptomicsDistinctive responses to nitrogen starvation in the dominant active mutants of the fission yeast Rheb GTPase.
Rheb, a ras-like small GTPase conserved from human to yeast, controls Tor kinase and plays a central role in regulation of cell growth depending on extracellular conditions. Fission yeast Rheb regulates amino acid uptake as well as response to nitrogen starvation. In this study we generated two muta...
ORGANISM(S): Schizosaccharomyces pombe 
2009-09-28 | E-GEOD-14626 | biostudies-arrayexpress
ProteomicsBistability in the Rac1, PAK and RhoA signalling network is a feature of cell motility.
Dynamic interactions between RhoA and Rac1, members of the Rho small GTPase family, play a vital role in the control of cell migration. Using predictive mathematical modelling and experimental validation in MDA-MB-231 mesenchymal breast cancer cells, we show that Rac1 and RhoA interactions via the P...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080751 | MassIVE
ProteomicsTargeted proteomic analysis of small GTPases in radioresistant breast cancer cells
Radiotherapy benefits more than 50% of cancer patients and cures 40% of them, where ionizing radiation deposits energy to cells and tissues, thereby eliciting DNA damage and resulting in cell death. Small GTPases are a superfamily of proteins that play critical roles in cell signaling. Several small...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD034360 | Pride
Breast cancer Radioresistance Radiation therapy Mrm Targeted proteomics Small gtpase 
UnknownA large Rab GTPase family in a small GTPase world.
Not available
S-EPMC5331893 | biostudies-literature
UnknownIQGAP1 is a key node within the small GTPase network.
Not available
S-EPMC4011815 | biostudies-literature
TranscriptomicsTranscriptome profiling of knock mutant and RNAi lines for small GTPase, nucleolar GTP-binding protein 1 (NOG1) in Arabidopsis
Gene expression profiling of knock out mutant NOG1-1 and RNAi line NOG1-2 was studied in comparison to wild type in leaves of seven days old plants.
ORGANISM(S): Arabidopsis thaliana 
2017-07-19 | E-MTAB-5946 | biostudies-arrayexpress
TranscriptomicsChanges in expression of small non-coding RNAs/microRNAs during aging in C. elegans
We report a significant number of miRNAs and other non-coding small RNAs show dramatic changes in expression during aging in C. elegans. RNAs were prepared from four diffrent timepoints during adulthood of C. elegans hermaphrodites, Day 0, 5, 8 and 12 post-L4 molt, and used for making cDNA libraries...
ORGANISM(S): Caenorhabditis elegans 
2009-12-31 | E-GEOD-18634 | biostudies-arrayexpress
TranscriptomicsBeta-tubulin and Actin Filament-Associating Small GTPase GIMAP4 is Required for IFN-Ɣ Secretion During Early Human CD4+ T Cell Activation
The aim of the dataset was to study on a genome-wide level the effect of GTPase of the human immune associated protein 4 (GIMAP4) knockdown on the gene expression of resting T cells and immediately after T cell activation and Th1(Act+IL12) polarizing conditions of human cord blood-derived CD4+ T cel...
ORGANISM(S): Homo sapiens 
2014-10-09 | E-GEOD-45720 | biostudies-arrayexpress
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