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TranscriptomicsPhosphorylation of p53 Serine 46 contributes to target gene selectivity of p53 (Exon)
The tumor suppressor p53 plays a crucial role in cellular growth control inducing a plethora of cellular response pathways. The molecular mechanisms that discriminate between the distinct p53-responses towards different stress treatments have remained largely elusive. Here, we have analyzed the p53-...
ORGANISM(S): Homo sapiens 
2011-03-23 | E-GEOD-22184 | biostudies-arrayexpress
GenomicsPhosphorylation of p53 Serine 46 contributes to target gene selectivity of p53 (ChIP-seq)
The tumor suppressor p53 plays a crucial role in cellular growth control inducing a plethora of cellular response pathways. The molecular mechanisms that discriminate between the distinct p53-responses towards different stress treatments have remained largely elusive. Here, we have analyzed the p53-...
ORGANISM(S): Homo sapiens 
2011-03-24 | E-GEOD-21939 | biostudies-arrayexpress
TranscriptomicsInterplay between c-Jun and TAp73M-NM-1/M-NM-2 contributes to the apoptosis-survival balance
The p53-family member p73 functions in various cellular signaling pathways and can have tumor suppressor properties. Several isoforms of p73 exist that differ considerably in their function. Whereas the functions of the N-terminal isoforms (TA and M-NM-^TNp73) and their opposing pro- and anti-apopto...
ORGANISM(S): Homo sapiens 
2011-03-01 | E-GEOD-15780 | biostudies-arrayexpress
TranscriptomicsATAC-seq to detect open chromatin sites in a selection of ovarian cancer cell lines
ATAC-seq was performed in the ovarian cancer cell lines COV-434, ES-2, Kuramochi, OAW28, OAW42, OVISE, SKOV-3, TOV-112D. The aim of this experiment was to detect open chromatin sites. Enhancers are associated with open chromatin sites flanked by histones with H3K4me1 and H3K27ac marks. Therefore, th...
ORGANISM(S): Homo sapiens 
2026-07-30 | E-MTAB-14770 | biostudies-arrayexpress
GenomicsHistone ChIP-seq for the detection of active elements (H3K4me1, H3K4me3, H3K27ac, input control) in a selection of cancer cell lines
Histone ChIP-seq was performed in the ovarian cancer cell lines COV-434, ES-2, Kuramochi, OAW28, OAW42, OVISE, SKOV-3, TOV-112D and several other cancer cell lines (BxPC-3, Caco2, Capan2, F36P, HEL, HT29, MDA-MB231, MDA-MB-468, MiaPaCa2, NCIH520, RERF-LC-MS, SkLu1, SW480, T47D and U-937). For the de...
ORGANISM(S): Homo sapiens 
2026-07-30 | E-MTAB-14771 | biostudies-arrayexpress
Transcriptomics4C-seq to detect the interaction of the EVI1 promoter (viewpoint of the experiment) with chromatin regulatory elements in a selection of ovarian cancer cell lines and other cancer cell lines
The EVI1 promoter was chosen as the viewpoint of the experiment. The purpose of this experiment was to detect potential cis-interactions of the EVI1 promoter with regulatory elements. 4C-seq was performed in the ovarian cancer cell lines COV-434, ES-2, Kuramochi, OAW28, OAW42, OVISE, SKOV-3, TOV-112...
ORGANISM(S): Homo sapiens 
2026-07-30 | E-MTAB-14772 | biostudies-arrayexpress
GenomicsThe B cell identity factor Pax5 regulates distinct transcriptional programs in early and late B lymphopoiesis
Pax5 controls the identity and development of B cells by repressing lineage-inappropriate genes and activating B-cell-specific genes. Here, we used genome-wide approaches to identify Pax5 target genes in pro-B and mature B cells. In these cell types, Pax5 bound to 40% of the cis- regulatory elements...
ORGANISM(S): Mus musculus 
2012-06-14 | E-GEOD-38046 | biostudies-arrayexpress
GenomicsGenome-wide profiling of p63 binding sites identifies genes and regulatory elements for p63-related disorders
We identified p63 target genes and binding sites responsible for ectodermal defects by genome-wide profiling of p63 binding using ChIP-seq and expression analysis in human primary keratinocytes from patients with p63 mutations. As proof of principle, we identified a novel de novo microdeletion causi...
ORGANISM(S): Homo sapiens 
2010-08-15 | E-GEOD-17611 | biostudies-arrayexpress
GenomicsMolecular role of the PAX5-ETV6 oncoprotein in promoting B cell acute lymphoblastic leukemia
PAX5 is a tumor suppressor in B-ALL, while the role of PAX5 fusion proteins in B-ALL development is largely unknown. Here we studied the function of PAX5-ETV6 and PAX5- FOXP1 in mice expressing these proteins from the Pax5 locus. Both proteins arrested Blymphopoiesis at the pro-B-to-pre-B cell trans...
ORGANISM(S): Mus musculus 
2016-07-30 | E-GEOD-84987 | biostudies-arrayexpress
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