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TranscriptomicsSynaptic activity-regulated gene expression_embryonic day 18
Activity-dependent changes in synapses rely on functional changes in resident proteins and on gene expression. We addressed the relationship between synapse activity and the expression of synaptic genes by comparing RNA levels in the neocortex of normal mice versus synaptically silent munc18-1 null ...
ORGANISM(S): Mus musculus 
2006-07-31 | E-GEOD-3639 | biostudies-arrayexpress
ProteomicsMultimodal Proteomics reveals dysregulated secretion and ECM remodeling in schizophrenia patient iPSC-derived astrocytes
Astrocytes are increasingly implicated in the pathophysiology of schizophrenia (SCZ), yet how astrocytic dysfunction contributes to disease-relevant neuronal abnormalities remains unclear. Here, we use mass spectrometry–based proteomics to profile lysates (proteome) and secreted (secretome) proteins...
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD075039 | Pride
Astrocytes Proteomics Ipsc Schizophrenia Protein secretion 
ProteomicsMS-DAP platform for label-free proteomics uncovers optimal workflows in benchmark datasets and increased sensitivity in analysis of Alzheimer's biomarker data
In the rapidly moving proteomics field, a diverse patchwork of algorithms for data normalization and differential expression analysis is used by the community. We generated an all-inclusive mass spectrometry downstream analysis pipeline (MS-DAP) that integrates many algorithms for normalization and ...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2023-03-10 | PXD036134 | Pride
Alzheimer’s disease Proteomics Software Benchmarking Bioinformatics 
ProteomicsGENETIC SUBTYPE- AND CELL TYPE-SPECIFIC PROTEIN SIGNATURES IN FRONTOTEMPORAL DEMENTIA
Frontotemporal dementia is characterized by progressive atrophy of frontal and/or temporal cortices and an early age of onset. The disorder is highly heterogenic, comprising several genetic causes as well as a diverse phenotypic landscape of sporadic cases. Here we investigated the proteomic signatu...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD022872 | Pride
Frontotemporal dementia  c9orf72  grn  mapt  human brain proteomics 
ProteomicsDistinct cell type-specific protein signatures in GRN and MAPT genetic subtypes of frontotemporal dementia
INTRODUCTION: Frontotemporal dementia (FTD) is characterized by progressive atrophy of frontal and/or temporal cortices and considerable clinical, pathological, and genetic heterogeneity. METHODS: Frontal and temporal cortex tissues from FTD-GRN (n=9), FTD-MAPT (n=13), and non-demented controls (n=1...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD031419 | Pride
Frontotemporal dementia  grn  mapt  human brain proteomics  cell type enrichment 
ProteomicsProteomics of the dentate gyrus reveals semantic dementia specific molecular pathology
Background Semantic dementia (SD) is a subtype of frontotemporal dementia (FTD) characterized by language deficits due to severe temporal lobe degeneration. The consistent neuropathological diagnosis is FTD-TDP subtype C, with characteristic round TDP-43 protein inclusions in the dentate gyrus. Desp...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD033060 | Pride
Semantic dementia Proteomics Mass spectrometry Frontotemporal dementia Tdp-43 
ProteomicsHuman brain prefrontal cortex proteomics identifies compromised energy metabolism and neuronal function in Schizophrenia
Understanding the pathophysiological substrates of schizophrenia is a major challenge for current neuropsychiatric research. As part of a set of multi-omics experiments, we performed an extensive case-control proteomics study on 192 post-mortem tissue sections from prefrontal cortex from 96 individu...
ORGANISM(S): Homo sapiens (Human) 
2026-03-09 | PXD058441 | Pride
TranscriptomicsMajor Depressive Disorder blood gene expression
Background: Major Depressive Disorder (MDD) is a moderately heritable disorder with a high lifetime prevalence. At present, laboratory blood tests to support MDD diagnosis are not available. Methods: We used a classifier approach on blood gene expression profiles of a unique set of non-medicated su...
ORGANISM(S): Homo sapiens 
2011-10-04 | E-GEOD-19738 | biostudies-arrayexpress
ProteomicsGRASPing experience-dependent protein expression signatures enriched for hippocampal engram cell synapses
Enhanced synaptic wiring onto sparsely distributed memory engram cells supports contextual memory storage and recall, with negative-valence memories exhibiting greater salience. Protein-level adaptations of input-specific synaptic connectivity onto hippocampal CA1 engram cells, however, remains larg...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-24 | PXD054892 | Pride
TranscriptomicsGenetics of the hippocampal transcriptome in mouse: a systematic survey and online neurogenomics resource
The Hippocampus Consortium data set provides estimates of mRNA expression in the adult hippocampus of 99 genetically diverse strains of mice including 67 BXD recombinant inbred strains, 13 CXB recombinant inbred strains, a diverse set of common inbred strains, and two reciprocal F1 hybrids. The hipp...
ORGANISM(S): Mus musculus 
2016-07-26 | E-GEOD-84767 | biostudies-arrayexpress
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