Copy number variation (CNV) of DNA segments has recently been identified as a major source of genetic diversity, but a more comprehensive understanding of the extent and phenotypic effect of this type of variation is only beginning to emerge. In this study we generated genome-wide expression data fr...
This model is from the article:
A metabolic model of the mitochondrion and its use in modelling diseases of the tricarboxylic acid cycle.
Smith AC, Robinson AJ. BMC Syst Biol.
2011 Jun 29;5(1):102. 21714867
,
Abstract:
...
This a model from the article:
A biophysically based mathematical model of unitary potential activity in
interstitial cells of Cajal.
Faville RA, Pullan AJ, Sanders KM, Smith NP. Biophys J
2008 Jul;95(1):88-104 18339738
,
A...
Interpreting proteomics data remains challenging due to the large number of proteins that are quantified by modern mass spectrometry methods. Weighted gene correlation network analysis (WGCNA) can identify groups of biologically related proteins using only protein intensity values by constructing pr...
Natural SIV infection of sooty mangabeys (SMs) does not progress to disease despite chronic virus replication. In contrast to pathogenic SIV infection of rhesus macaques (RMs), chronic SIV infection of SMs is characterized by low immune activation. To elucidate the mechanisms underlying this phenoty...
Identifying sex differences in gene expression within the brain is critical for determining why multiple neurological and behavioural disorders differentially affect males and females. Several are more common or severe in males (e.g., autism and schizophrenia) or females (e.g., Alzheimer’s disease...
Sweat is emerging as a prominent biosource for real-time human performance monitoring applications. Although promising, sources of variability must be identified to truly utilize sweat for biomarker applications. In this proof-of-concept study, a targeted metabolomics method was applied to sweat col...
