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TranscriptomicsIdentification of direct T-box target genes in the developing zebrafish mesoderm
The zebrafish genes spadetail (spt) and no tail (ntl) encode T-box transcription factors that are important for early mesoderm development. Although much has been done to characterize these genes, the identity and location of target regulatory elements remain largely unknown. Here, we survey the gen...
ORGANISM(S): Danio rerio 
2010-05-19 | E-GEOD-12857 | biostudies-arrayexpress
UnknownValidation and analysis of 12,000 AI-driven CAR-T designs in the
Not available
S-SCDT-10_1038-S44320-026-00246-1 | biostudies-other
ProteomicsDual-acting IspH inhibitors kill Gram-negative bacteria and mobilize immune clearance
Isoprenoids are vital to all organisms in supporting core functions of life, like respiration and membrane stability. IspH, an enzyme in the methyl erythritol phosphate pathway of isoprenoid synthesis, is essential to gram-negative bacteria, mycobacteria and apicomplexans. The IspH substrate, HMBPP,...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) 
2020-10-22 | MSV000086359 | MassIVE
ProteomicsXanthohumol Activity-Based Probes Targeting Flavonoid Catabolism
Xanthohumol, the principle prenylflavonoid found in hops (Humulus lupulus), is a potential anti-inflammatory agent in the gut. To investigate the interactions between xanthohumol and catabolic gut bacteria, and its role in the anti-inflammatory pathway, a suite of xanthohumol-derived activity-based ...
ORGANISM(S): Eubacterium Ramulus (ncbitaxon:39490) Escherichia Coli (ncbitaxon:562) 
2022-02-04 | MSV000088789 | MassIVE
ProteomicsInduction of active hepatic cytochrome P450 enzymes in mice exposed to benzo[a]pyrene or environmental mixtures of polycyclic aromatic hydrocarbons
Cytochrome P450 enzymes play an important role in bioactivating or detoxifying polycyclic aromatic hydrocarbons (PAHs). We exposed mice to doses of benzo[a]pyrene (BaP) or a mixture of PAHs to characterize dose- and time-response relationships of specific cytochrome P450s. Mice exposed to the highes...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-13 | PXD019472 | Pride
Enyzme induction Chemoproteomics Polycyclic aromatic hydrocarbons Cytochrome p450 
ProteomicsChemical profiling of live cell temporal redox dynamics in a photoautotrophic cyanobacterium
We have developed a quantitative chemical probe approach for live cell labeling of proteins that are sensitive to redox modifications. We utilize this in vivo strategy coupled to mass spectrometry-based proteomics to identify 176 proteins undergoing ~5-10 fold dynamic redox change in response to nut...
ORGANISM(S): Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum) 
2015-08-24 | PXD000329 | Pride
Cyanobacteria Photosynthesis Chemical profiling Redox Biofuels 
UnknownClinical parameters model for predicting pathologic complete response following preoperative chemoradiation in patients with esophageal cancer.
Not available
S-EPMC3457750 | biostudies-literature
ProteomicsFetal to adult ontogeny of human cytochrome P450 activity, abundance, and expression
Activity-based and global proteomic analysis of fetal through late adulthood human samples, with a primary focus on cytochrome P450 enzyme expression and functional activity
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD002781 | Pride
Activity-based proteomics Ontogeny Cytochrome p450 
UnknownIn vivo electroporation enhances the immunogenicity of an HIV-1 DNA vaccine candidate in healthy volunteers.
Not available
S-EPMC3095594 | biostudies-literature
ProteomicsA Survey of Serine Hydrolase Activity in Mycobacterium tuberculosis
Changes in Serine Hydrolase Activity Associated with Mycobacterium tuberculosis Replication
ORGANISM(S): Mycobacterium tuberculosis 
2016-02-01 | PXD002763 | Pride
Replication Serine hydrolase 
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