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MetabolomicsIntegrative Modeling of Quantitative Plasma Lipoprotein, Metabolic, and Amino Acid Data Reveals a Multiorgan Pathological Signature of SARS-CoV-2 Infection
The metabolic effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on human blood plasma were characterized using multi-platform metabolic phenotyping with Nuclear Magnetic Resonance (NMR) spectroscopy and liquid chromatography-mass spectrometry (LC-MS). Quantitative mea...
2021-01-29 | MTBLS2014 | MetaboLights
UnknownSignalling lymphocyte activation molecule family member 9 is found on select subsets of antigen-presenting cells and promotes resistance to Salmonella infection.
Not available
S-EPMC7078004 | biostudies-literature
UnknownLeupaxin Expression Is Dispensable for B Cell Immune Responses.
Not available
S-EPMC7109257 | biostudies-literature
UnknownHumoral responses to SARS-CoV-2 vaccine in vasculitis-related immune suppression.
Not available
S-EPMC11817922 | biostudies-literature
ProteomicsEROS/CYBC1 CONTROLS THE PHAGOCYTE RESPIRATORY BURST VIA DIRECT INTERACTION WITH GP91PHOX AND HAS A NOVEL ROLE IN NLRP3 INFLAMMASOME ACTIVATION
EROS (Essential for Reactive Oxygen Species) protein (CYBC1) is indispensable for expression of the gp91phox-p22phox heterodimer of the phagocyte NADPH oxidase. EROS deficiency in humans is a novel cause of chronic granulomatous disease (CGD) but its mechanism of action remains unclear. Our work des...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD024659 | Pride
Chronic granulomatous disease Eros P2x7 Cybc1 Gp91phox Nadph oxidase 
UnknownIntratumoral antigen signaling traps CD8<sup>+</sup> T cells to confine exhaustion to the tumor site.
Not available
S-EPMC7616235 | biostudies-literature
ProteomicsEROS is a selective chaperone regulating the phagocyte NADPH oxidase and purinergic signalling.
The phagocyte NADPH oxidase is critical for host defence, and EROS (Essential for Reactive Oxygen Species) protein is indispensable for expression of its gp91phox-p22phox heterodimer. EROS deficiency in humans is a recently described cause of chronic granulomatous disease (CGD), but its mechanism of...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-30 | PXD025149 | Pride
Nox family Inflammasome Nadph oxidase Ost complex Chaperone T cells P2x receptor Er 
ProteomicsProteomic analysis of circulating immune cells identifies novel cellular phenotypes associated with COVID-19 severity
Certain serum proteins, including CRP and D-dimer, have prognostic value in patients with SARS-CoV-2 infection. Nonetheless, these factors are non-specific, and provide limited mechanistic insight into the peripheral blood mononuclear cell (PBMC) populations which drive the pathogenesis of severe CO...
ORGANISM(S): Homo sapiens (Human) 
2023-03-29 | PXD040703 | Pride
Covid-19 Pbmc Cell surface Sars-cov-2 Plasma membrane Phenotype Biomarker 
UnknownOne Gene, Many Facets: Multiple Immune Pathway Dysregulation in SOCS1 Haploinsufficiency.
Not available
S-EPMC8375263 | biostudies-literature
UnknownSec22b is a critical and nonredundant regulator of plasma cell maintenance.
Not available
S-EPMC9926242 | biostudies-literature
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