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UnknownProlonged administration of azacitidine with or without entinostat for myelodysplastic syndrome and acute myeloid leukemia with myelodysplasia-related changes: results of the US Leukemia Intergroup trial E1905.
Not available
S-EPMC3986386 | biostudies-literature
MetabolomicsMetabolic phenotyping of urine from a dementia research cohort
To better understand the molecular mechanisms underpinning physiological variation in human populations, metabolic phenotyping approaches are increasingly being applied to studies involving hundreds and thousands of biofluid samples. Hyphenated ultra-performance liquid chromatography-mass spectromet...
2022-03-01 | MTBLS719 | MetaboLights
TranscriptomicsCUT&RUN LoV-U of beta-catenin, TCF/LEF transcription factors and histone modifications in HEK293T and mouse embryonic hindlimb tissue at 11.5 days post coitum
In our attempts to profile different regulators of the WNT/b-catenin transcriptional complex, CUT&RUN failed to produce consistent binding patterns of the non-DNA-binding b-catenin. We developed a modified CUT&RUN protocol, which we refer to as LoV-U (Low Volume and Urea), that enables the generatio...
ORGANISM(S): Mus musculus 
2022-07-16 | E-MTAB-11951 | biostudies-arrayexpress
GenomicsGenome-wide distribution of 5-formylcytosine in ES cells is associated with transcription and depends on TDG
Methylation of cytosine in DNA (5mC) is an important epigenetic mark that is involved in the regulation of genome function. During early embryonic development in mammals, the DNA methylation landscape is dynamically reprogrammed in part through active demethylation. Recent advances have identified k...
ORGANISM(S): Mus musculus 
2012-08-17 | E-GEOD-40148 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization by array of Streptococcus pneumoniae isolates from the Mitis group to identify pneumococcal virulance genes
Data is also available from BuG@Sbase
ORGANISM(S): Streptococcus pneumoniae 
2010-07-22 | E-BUGS-82 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of field-caught permethrin-resistant Anopheles gambiae shows over-expression of CYP6P3, a P450 that metabolizes pyrethroids
Field-caught permethrin-resistant Anopheles gambiae s.s. overexpress CYP6P3, a P450 that metabolizes pyrethroids
ORGANISM(S): Anopheles gambiae s.s. 
2009-01-17 | E-MTAB-52 | biostudies-arrayexpress
TranscriptomicsLaser Capture Microdissection of Hyperlipidemic Mouse Aorta Atherosclerosis
Atherosclerosis is a transmural chronic inflammatory condition of small and large arteries that is associated with adaptive immune responses at all disease stages. However, impacts of adaptive immune reactions on clinically apparent atherosclerosis such as intima lesion (plaque) rupture, thrombosis,...
ORGANISM(S): Mus musculus 
2011-11-03 | E-GEOD-21419 | biostudies-arrayexpress
TranscriptomicsMucosal transcriptomics implicates under expression of FAM5C in the pathogenesis of ulcerative colitis
Background and aims: Mucosal abnormalities are potentially important in the primary pathogenesis of ulcerative colitis (UC). We investigated the mucosal transcriptomic expression profiles of biopsies from patients with UC and healthy controls (HC), taken from macroscopically non-inflamed tissue fr...
ORGANISM(S): Homo sapiens 
2014-09-05 | E-GEOD-48634 | biostudies-arrayexpress
ProteomicsRetinal pigment epithelium extracellular vesicles are potent inducers of age-related macular degeneration disease phenotype in the outer retina
Age-related macular degeneration (AMD) is a leading cause of blindness. Vision loss is caused by the loss of the retinal pigment epithelium (RPE) and photoreceptors and/or retinal and choroidal angiogenesis. Here we use AMD patient specific RPE cells with the Y402H high-risk polymorphism in the comp...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-01-21 | MSV000088713 | MassIVE
TranscriptomicsCUT&RUN experiment at four time points in HEK293T and hESC cells, assessing the time-resolved response of β-catenin genomic occupancy upon Wnt signaling activation
Wnt/β-catenin signaling is a highly organized biochemical cascade that triggers a gene expression program in the signal-receiving cell. The Wnt/β-catenin-driven transcriptional response is involved in virtually all cellular processes during development, homeostasis, and its deregulation causes human...
ORGANISM(S): Homo sapiens 
2022-09-30 | E-MTAB-12077 | biostudies-arrayexpress
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